S
Stephan Brand
Researcher at Ludwig Maximilian University of Munich
Publications - 166
Citations - 19879
Stephan Brand is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 57, co-authored 161 publications receiving 18149 citations. Previous affiliations of Stephan Brand include Kantonsspital St. Gallen & Hochschule Hannover.
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Journal ArticleDOI
Correlation of magnetic resonance enteroclysis (MRE) and wireless capsule endoscopy (CE) in the diagnosis of small bowel lesions in Crohn's disease
Cornelia Tillack,Julia Seiderer,Stephan Brand,Burkhard Göke,Maximilian F. Reiser,Claus Schaefer,Helmut M. Diepolder,Thomas Ochsenkühn,Karin A. Herrmann +8 more
TL;DR: MRE is inferior in the detection of superficial mucosal disease but reliably discloses the presence of severe inflammatory changes within the bowel wall and beyond, which may be underestimated from the endoscopic aspect of the mucosal surface.
Journal ArticleDOI
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population.
Jürgen Glas,Astrid Konrad,Silke Schmechel,Julia Dambacher,Julia Seiderer,Frieder Schroff,Martin Wetzke,D. Roeske,Helga-Paula Török,Laurian Tonenchi,Simone Pfennig,Dirk Haller,Thomas Griga,Wolfram Klein,Jörg T. Epplen,Christian Folwaczny,Peter Lohse,Burkhard Göke,Thomas Ochsenkühn,Thomas Mussack,Matthias Folwaczny,Bertram Müller-Myhsok,Stephan Brand +22 more
TL;DR: ATG16L1 mRNA expression was not upregulated in CD and murine ileitis, and was less than threefold increased in cells stimulated with proinflammatory cytokines and TLR ligands.
Journal ArticleDOI
IL-22-mediated liver cell regeneration is abrogated by SOCS-1/3 overexpression in vitro.
Stephan Brand,Julia Dambacher,Florian Beigel,Kathrin Zitzmann,Malte H.J. Heeg,Thomas S. Weiss,Thomas Prüfer,Torsten Olszak,Christian J. Steib,Martin Storr,Burkhard Göke,Helmut M. Diepolder,Manfred Bilzer,Wolfgang E. Thasler,Christoph J. Auernhammer +14 more
TL;DR: The IL-10-like cytokine IL-22 is produced by activated T cells and the role of this cytokine system in hepatic cells is analyzed in this study.
Journal ArticleDOI
Novel interferon-λs induce antiproliferative effects in neuroendocrine tumor cells
Kathrin Zitzmann,Stephan Brand,Sebastian Baehs,Burkhard Göke,Jennifer Meinecke,Gerald Spöttl,Heinrich H. D. Meyer,Christoph J. Auernhammer +7 more
TL;DR: The novel IFN-lambdas IL-28A and IL-29 potently induce STAT signaling and antiproliferative effects in neuroendocrine BON1 tumor cells, which may hint a promising new approach in the antiprolliferative therapy of neuro endocrine tumors.
Journal ArticleDOI
A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn’s Disease and Human Gut Microbiome Composition
Dalin Li,Jean Paul Achkar,Talin Haritunians,Jonathan P. Jacobs,Ken Y. Hui,Mauro D'Amato,Stephan Brand,Graham L. Radford-Smith,Graham L. Radford-Smith,Graham L. Radford-Smith,Jonas Halfvarson,Jan Hendrik Niess,Jan Hendrik Niess,Subra Kugathasan,Carsten Büning,L. Philip Schumm,Lambertus Klei,Ashwin N. Ananthakrishnan,Guy Aumais,Guy Aumais,Leonard Baidoo,Marla Dubinsky,Marla Dubinsky,Claudio Fiocchi,Jürgen Glas,Raquel Milgrom,Deborah D. Proctor,Miguel Regueiro,Lisa A. Simms,Joanne M. Stempak,Stephan R. Targan,Leif Törkvist,Leif Törkvist,Yashoda Sharma,Bernie Devlin,James Borneman,Hakon Hakonarson,Ramnik J. Xavier,Ramnik J. Xavier,Mark J. Daly,Mark J. Daly,Steven R. Brant,John D. Rioux,John D. Rioux,Mark S. Silverberg,Judy H. Cho,Jonathan Braun,Dermot P.B. McGovern,Richard H. Duerr +48 more
TL;DR: The results suggest that an SLC39A8-dependent shift in the gut microbiome could explain its pleiotropic effects on multiple complex diseases including CD.