Stephan Söder

TL;DR: The data characterize SW1353 cells as a cell line with only a very limited potential to mimic PHCs, though SW13 53 cells can be of value to study the induction of protease expression within cells, a phenomenon also seen in chondrocytes.

TL;DR: Tissue architecture and matrix composition in mature osteophytes suggests that metaplastic neo-cartilagenous tissue might be one potential source of cartilage repair tissue in the adult joint.

TL;DR: It is demonstrated that DC subpopulations in organs of the lymphohematopoietic system (spleen, thymus, and blood) are strongly defined by ontogeny rather than by signals from the microenvironment, strongly arguing that DCs react toward modulatory signals from tissue microenvironments.

TL;DR: The authors' immunohistochemical and ultrastructural data are compatible with two ways of degradation of type VI collagen in osteoarthritic cartilage: the pathologically increased physiological molecular degradation leading to the complete loss oftype VI collagen filaments from the pericellular chondrocyte matrix and the transformation of the fine filaments to the band-like form of type VII collagen.

TL;DR: The results suggest that at least in human adult articular cartilage the C5 domain of alpha3(VI) collagen is synthesized and initially incorporated into the newly formed type VI collagen fibrils, but immediately after secretion is cut off and is not present in the mature pericellular type VI matrix of articular Cartilage.