K
Katharina C. Reimer
Researcher at University of Erlangen-Nuremberg
Publications - 5
Citations - 167
Katharina C. Reimer is an academic researcher from University of Erlangen-Nuremberg. The author has contributed to research in topics: Induced pluripotent stem cell & Kidney. The author has an hindex of 2, co-authored 2 publications receiving 125 citations.
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Journal ArticleDOI
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment
Gordon F. Heidkamp,Jil Sander,Christian H. K. Lehmann,Lukas Heger,Nathalie Eissing,Anna Baranska,Jennifer J. Lühr,Alana Hoffmann,Katharina C. Reimer,Anja Lux,Stephan Söder,Arndt Hartmann,Johannes Zenk,Thomas Ulas,Naomi McGovern,Christoph Alexiou,Bernd M. Spriewald,Andreas Mackensen,Gerold Schuler,Burkhard Schauf,Anja Forster,Roland Repp,Peter A. Fasching,Ariawan Purbojo,Robert Cesnjevar,Evelyn Ullrich,Evelyn Ullrich,Florent Ginhoux,Andreas Schlitzer,Andreas Schlitzer,Andreas Schlitzer,Falk Nimmerjahn,Joachim L. Schultze,Joachim L. Schultze,Diana Dudziak +34 more
TL;DR: It is demonstrated that DC subpopulations in organs of the lymphohematopoietic system (spleen, thymus, and blood) are strongly defined by ontogeny rather than by signals from the microenvironment, strongly arguing that DCs react toward modulatory signals from tissue microenvironments.
Journal ArticleDOI
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H. K. Lehmann,Anna Baranska,Anna Baranska,Gordon F. Heidkamp,Lukas Heger,Kirsten Neubert,Jennifer J. Lühr,Alana Hoffmann,Katharina C. Reimer,Christin Brückner,Simone Beck,Michaela Seeling,Melissa Kießling,Didier Soulat,Anne Krug,Jeffrey V. Ravetch,Jeanette H. W. Leusen,Falk Nimmerjahn,Diana Dudziak +18 more
TL;DR: It is shown that antigen uptake under steady-state conditions results in a short-term expansion of antigen-specific T cells, whereas under inflammatory conditions especially, the activating Fc&ggr;RIV is able to induce superior CD4+ and CD8+ T cell responses.
SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
Jitske Jansen,Katharina C. Reimer,James Shiniti Nagai,Finny S. Varghese,Gijs J. Overheul,M. De Beer,Rona C. Roverts,Deniz Daviran,Liline A. S. Fermin,Brigith Willemsen,Marcel Beukenboom,Sonja Djudjaj,Saskia von Stillfried,Larissa E. van Eijk,Mirjam F. Mastik,Marian Bulthuis,Wilfred F. A. den Dunnen,Harry van Goor,Jan-Luuk Hillebrands,Sergio Triana,Theodore Alexandrov,Marieke Timm,Bartholomeus T. van den Berge,Martijn van den Broek,Quincy Nlandu,Joelle Heijnert,Eric M.J. Bindels,Remco Hoogenboezem,Fieke Mooren,Christoph Kuppe,Pascal Miesen,Ties IJzermans,Eric J. Steenbergen,Jan Czogalla,Michiel F. Schreuder,Nico A. J. M. Sommerdijk,Anat Akiva,Peter Boor,Victor G. Puelles,urgen Floege,Tobias B. Huber,Ronald P. van Rij,Ivan G. Costa,Rebekka K. Schneider,Bart Smeets,Rafael Kramann +45 more
TL;DR: The results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequentrosis in COVID-19 patients and a potential upregulation of fibrosis-driving pathways and increased renal matrix expression in CO VID-19.
Journal ArticleDOI
Using human iPSC-derived kidney organoids to decipher SARS-CoV-2 pathology on single cell level
Katharina C. Reimer,Jitske Jansen,Gijs J. Overheul,Pascal Miesen,Ronald P. van Rij,Sergio Triana,Bart Smeets,Rebekka K. Schneider,Rafael Kramann +8 more
TL;DR: Jansen et al. as mentioned in this paper described a protocol for single-cell RNA sequencing of SARS-CoV-2-infected human induced pluripotent stem cell (iPSC)-derived kidney organoids.
Journal ArticleDOI
Protocol to analyze bioenergetics in single human induced-pluripotent-stem-cell-derived kidney organoids using Seahorse XF96
Verónica Miguel,Katharina C. Reimer,Anna Katharina Galyga,Jitske Jansen,Julia Möllmann,Luisa Meyer,Rebekka K. Schneider,Rafael Kramann +7 more
TL;DR: In this article , a fine-tuned protocol was presented to analyze bioenergetics in single human induced-pluripotent-stem-cell (iPSC)-derived kidney organoids using Seahorse XF96.