S
Stéphane Peyrégne
Researcher at Max Planck Society
Publications - 17
Citations - 1211
Stéphane Peyrégne is an academic researcher from Max Planck Society. The author has contributed to research in topics: Population & Denisovan. The author has an hindex of 9, co-authored 15 publications receiving 801 citations. Previous affiliations of Stéphane Peyrégne include Centre national de la recherche scientifique & Pasteur Institute.
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Journal ArticleDOI
A high-coverage Neandertal genome from Vindija Cave in Croatia
Kay Prüfer,Cesare de Filippo,Steffi Grote,Fabrizio Mafessoni,Petra Korlević,Mateja Hajdinjak,Benjamin Vernot,Laurits Skov,PingHsun Hsieh,Stéphane Peyrégne,David Reher,Charlotte Hopfe,Sarah Nagel,Tomislav Maricic,Qiaomei Fu,Christoph Theunert,Christoph Theunert,Rebekah L. Rogers,Pontus Skoglund,Manjusha Chintalapati,Michael Dannemann,Bradley J. Nelson,Felix M. Key,Pavao Rudan,Željko Kućan,Ivan Gušić,Liubov V. Golovanova,Vladimir B. Doronichev,Nick Patterson,David Reich,David Reich,David Reich,Evan E. Eichler,Montgomery Slatkin,Mikkel H. Schierup,Aida M. Andrés,Janet Kelso,Matthias Meyer,Svante Pääbo +38 more
TL;DR: The genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, is sequenced to ~30-fold genomic coverage, allowing 10 to 20% more Ne andertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
Journal ArticleDOI
The genome of the offspring of a Neanderthal mother and a Denisovan father
Viviane Slon,Fabrizio Mafessoni,Benjamin Vernot,Cesare de Filippo,Steffi Grote,Bence Viola,Bence Viola,Mateja Hajdinjak,Stéphane Peyrégne,Sarah Nagel,Samantha Brown,Katerina Douka,Katerina Douka,Thomas Higham,M.B. Kozlikin,Michael V. Shunkov,Michael V. Shunkov,Anatoly P. Derevianko,Janet Kelso,Matthias Meyer,Kay Prüfer,Svante Pääbo +21 more
TL;DR: The genome of ‘Denisova 11’, a bone fragment from Denisova Cave (Russia) is presented and it is shown that it comes from an individual who had a Neanderthal mother and a Denisovan father.
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A high-coverage Neandertal genome from Chagyrskaya Cave
Fabrizio Mafessoni,Steffi Grote,Cesare de Filippo,Viviane Slon,Kseniya Kolobova,Bence Viola,S. V. Markin,Manjusha Chintalapati,Stéphane Peyrégne,Laurits Skov,Pontus Skoglund,A.I. Krivoshapkin,Anatoly P. Derevianko,Matthias Meyer,Janet Kelso,Benjamin M. Peter,Kay Prüfer,Svante Pääbo,Svante Pääbo +18 more
TL;DR: The genome of a Neandertal from Chagyrskaya Cave in the Altai Mountains, Russia, is sequenced to 27-fold genomic coverage and it is found that genes highly expressed in the Striatum in the basal ganglia of the brain carry more amino-acid-changing substitutions than genes expressed elsewhere in the brain, suggesting that the striatum may have evolved unique functions in NeandERTals.
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Detecting ancient positive selection in humans using extended lineage sorting.
TL;DR: A method for detecting ancient selective sweeps by scanning for extended genomic regions where the authors' closest extinct relatives, Neandertals and Denisovans, fall outside of the present-day human variation and presents a list of genomic regions that are predicted to underlie positively selected human specific traits.
Journal ArticleDOI
Nuclear DNA from two early Neandertals reveals 80,000 years of genetic continuity in Europe
Stéphane Peyrégne,Viviane Slon,Fabrizio Mafessoni,Cesare de Filippo,Mateja Hajdinjak,Sarah Nagel,Birgit Nickel,Elena Essel,Adeline Le Cabec,Kurt Wehrberger,Nicholas J. Conard,Claus Joachim Kind,Cosimo Posth,Johannes Krause,Grégory Abrams,Dominique Bonjean,Kévin Di Modica,Michel Toussaint,Janet Kelso,Matthias Meyer,Svante Pääbo,Kay Prüfer +21 more
TL;DR: Nasa retrieved nuclear genomic sequences from two Neandertals, one from Hohlenstein-Stadel Cave in Germany and the other from Scladina Cave in Belgium, who lived around 120,000 years ago, revealing the deep population history of European Ne andertals.