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Stéphanie Bonnafous
Researcher at French Institute of Health and Medical Research
Publications - 21
Citations - 1349
Stéphanie Bonnafous is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Adipose tissue & Steatohepatitis. The author has an hindex of 15, co-authored 21 publications receiving 1175 citations. Previous affiliations of Stéphanie Bonnafous include University of Nice Sophia Antipolis.
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Journal ArticleDOI
Matrix Metalloproteinases Are Differentially Expressed in Adipose Tissue during Obesity and Modulate Adipocyte Differentiation
Carine Chavey,Bernard Mari,Marie-Noëlle Monthouel,Stéphanie Bonnafous,Patrick Anglard,Emmanuel Van Obberghen,Sophie Tartare-Deckert +6 more
TL;DR: Findings support a role for the MMP/TIMP system in the control of proteolytic events and adipogenesis during obesity-mediated fat mass development.
Journal ArticleDOI
Elevated Expression of Osteopontin May Be Related to Adipose Tissue Macrophage Accumulation and Liver Steatosis in Morbid Obesity
Adeline Bertola,Vanessa Deveaux,Stéphanie Bonnafous,Déborah Rousseau,Rodolphe Anty,Abdelilah Wakkach,Moncef Dahman,Joan Tordjman,Karine Clément,S. McQuaid,Keith N. Frayn,Pierre-Michel Huet,Jean Gugenheim,Sophie Lotersztajn,Yannick Le Marchand-Brustel,Albert Tran,Philippe Gual +16 more
TL;DR: The modestly elevated circulating OPN levels in morbidly obese patients were not related to liver steatosis and did not appear to result from adipose tissue secretion, and in subcutaneous AT, expression of OPN was directly related to macrophage accumulation independently from liver complications.
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Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells.
Luciano Pirola,Stéphanie Bonnafous,Anne M. Johnston,Claire Chaussade,Fiorella Portis,Emmanuel Van Obberghen +5 more
TL;DR: Reduction in IRS proteins via different PI3K-mediated mechanisms contributes to the development of an insulin-resistant state in L6 myoblasts, as knockdown of IRS-2 by RNA interference severely impaired activation of both kinases.
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CD44 is a key player in non-alcoholic steatohepatitis
Stéphanie Patouraux,Déborah Rousseau,Stéphanie Bonnafous,Cynthia Lebeaupin,Carmelo Luci,Clémence M. Canivet,Anne-Sophie Schneck,Adeline Bertola,Marie-Christine Saint-Paul,Antonio Iannelli,Jean Gugenheim,Rodolphe Anty,Albert Tran,Béatrice Bailly-Maitre,Philippe Gual +14 more
TL;DR: Human and experimental data suggest that CD44, a cellular protein mainly expressed in immune cells, is a marker and key player of hepatic inflammation and its targeting partially corrects NASH, making it a potential therapeutic strategy.
Journal ArticleDOI
Expression of myotubularin by an adenoviral vector demonstrates its function as a phosphatidylinositol 3-phosphate [PtdIns(3)P] phosphatase in muscle cell lines: involvement of PtdIns(3)P in insulin-stimulated glucose transport.
Claire Chaussade,Luciano Pirola,Stéphanie Bonnafous,François Blondeau,Stefano Brenz-Verca,Hélène Tronchère,Fiorella Portis,Sandro Rusconi,Bernard Payrastre,Jocelyn Laporte,E Van Obberghen +10 more
TL;DR: It is concluded that myotubularin plays a role in the control of vesicular traffic related to glucose transport, by counteracting the activities of the PtdIns(3)P-producing phosphatidylinositol 3-kinases.