Bernard Payrastre

TL;DR: A structure-activity study indicated that the position, number and substitution of the hydroxyl group of the B ring, and saturation of the C2-C3 bond are important factors affecting flavonoid inhibition of PI 3-kinase.

TL;DR: It is shown that ING2, a candidate tumor suppressor protein, is a nuclear PtdInsP receptor, and suggested that PHD-phosphoinositide interactions directly regulate nuclear responses to DNA damage.

TL;DR: Inhibitors and a dominant negative mutation were used to demonstrate that efficient entry requires the phosphoinositide (PI) 3-kinase p85α-p110 in bacterial entry, and may have parallels in some endocytic events.

TL;DR: The yeast Kes1p/Osh4p protein functions as a sterol/PI(4)P exchanger between lipid membranes, which suggests the possibility of creating a sterOL gradient via phosphoinositide metabolism.

TL;DR: Upon infection of epithelial cells with the Gram‐negative pathogen Shigella flexneri, the virulence factor IpgD is translocated directly into eukaryotic cells and acts as a potent inositol 4‐phosphatase that specifically dephosphorylates phosphatidylinositol4,5‐bisphosphate into phosphatin cytoskeleton organization that then accumulates.