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Stephen A. Sastra
Researcher at Columbia University Medical Center
Publications - 19
Citations - 2044
Stephen A. Sastra is an academic researcher from Columbia University Medical Center. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 8, co-authored 11 publications receiving 1577 citations. Previous affiliations of Stephen A. Sastra include Columbia University.
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Journal ArticleDOI
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma
Andrew D. Rhim,Andrew D. Rhim,Paul E. Oberstein,Dafydd H. Thomas,Emily T. Mirek,Carmine F. Palermo,Stephen A. Sastra,Erin N. Dekleva,Tyler Saunders,Claudia P. Becerra,Ian W. Tattersall,C. Benedikt Westphalen,Jan Kitajewski,Maite G. Fernandez-Barrena,Martin E. Fernandez-Zapico,Christine A. Iacobuzio-Donahue,Kenneth P. Olive,Ben Z. Stanger +17 more
TL;DR: De deleting Shh in a well-defined mouse model of PDAC demonstrated that some components of the tumor stroma can act to restrain tumor growth, and administration of VEGFR blocking antibody selectively improved survival of Shh-deficient tumors.
Journal ArticleDOI
Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging
Stefan Harmsen,Ruimin Huang,Matthew A. Wall,Matthew A. Wall,Hazem Karabeber,Jason M. Samii,Massimiliano Spaliviero,Julie R. White,Sebastien Monette,Rachael O'Connor,Kenneth L. Pitter,Stephen A. Sastra,Michael Saborowski,Eric C. Holland,Samuel Singer,Kenneth P. Olive,Scott W. Lowe,Scott W. Lowe,Ronald G. Blasberg,Moritz F. Kircher +19 more
TL;DR: The precise visualization of tumor margins, microscopic tumor invasion, and multifocal locoregional tumor spread is shown using a new generation of surface-enhanced resonance Raman scattering nanoparticles, which are termed SERRS nanostars.
Book ChapterDOI
Quantification of murine pancreatic tumors by high-resolution ultrasound.
TL;DR: A detailed method for performing high-resolution ultrasound to detect and measure pancreatic lesions in a genetically engineered mouse model of pancreatic ductal using the VisualSonics Vevo2100 High Resolution Ultrasound System is described.
Journal ArticleDOI
Preclinical Pharmacologic Evaluation of Pralatrexate and Romidepsin Confirms Potent Synergy of the Combination in a Murine Model of Human T-cell Lymphoma
Salvia Jain,Xavier Jirau-Serrano,Kelly Zullo,Luigi Scotto,Carmine F. Palermo,Stephen A. Sastra,Kenneth P. Olive,Serge Cremers,Tiffany Thomas,Ying Wei,Yuan Zhang,Govind Bhagat,Jennifer E Amengual,Changchun Deng,Charles Karan,Ronald Realubit,Susan E. Bates,Owen A. O'Connor +17 more
TL;DR: It is suggested that the combination of pralatrexate and romidepsin merits clinical study in patients with TCLs using complementary imaging modalities, such as SBL and 3D-US.
Journal ArticleDOI
Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo.
Alireza Nabavizadeh,Thomas Payen,Alina Iuga,Irina Sagalovskiy,Deborah D. Desrouilleres,Niloufar Saharkhiz,Carmine F. Palermo,Stephen A. Sastra,Paul E. Oberstein,Vilma L. Rosario,Michael D. Kluger,Beth Schrope,John A. Chabot,Kenneth P. Olive,Elisa E. Konofagou +14 more
TL;DR: HME, a quantitative ultrasound-based imaging method, was applied to calculate Young's modulus (YM) in PDAC mouse models and human pancreatic resection specimens of PDAC to develop a non-invasive, quantitative imaging tool for detecting, staging and delineating PDAC tumor margins based on the change in collagen density.