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Irina Sagalovskiy
Researcher at Columbia University
Publications - 7
Citations - 664
Irina Sagalovskiy is an academic researcher from Columbia University. The author has contributed to research in topics: SLC7A11 & Pancreatic cancer. The author has an hindex of 5, co-authored 6 publications receiving 283 citations. Previous affiliations of Irina Sagalovskiy include Columbia University Medical Center.
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Journal ArticleDOI
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Michael A. Badgley,Daniel M. Kremer,H. Carlo Maurer,H. Carlo Maurer,Kathleen E. DelGiorno,Ho-Joon Lee,Vinee Purohit,Irina Sagalovskiy,Alice Ma,Jonathan Kapilian,Christina E. M. Firl,Amanda R. Decker,Steve A. Sastra,Carmine F. Palermo,Leonardo R. Andrade,Peter Sajjakulnukit,Li Zhang,Zachary P. Tolstyka,Tal Hirschhorn,Candice Lamb,Tong Liu,Wei Gu,E. Scott Seeley,Everett Stone,George Georgiou,Uri Manor,Alina Iuga,Geoffrey M. Wahl,Brent R. Stockwell,Costas A. Lyssiotis,Kenneth P. Olive +30 more
TL;DR: This work shows that the import of oxidized cysteine (cystine) via system xC– is a critical dependency of pancreatic ductal adenocarcinoma (PDAC), which is a leading cause of cancer mortality.
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Comprehensive characterisation of compartment-specific long non-coding RNAs associated with pancreatic ductal adenocarcinoma.
Luis Arnes,Zhaoqi Liu,Jiguang Wang,Carlo Maurer,Irina Sagalovskiy,Marta Sanchez-Martin,Nikhil Bommakanti,Diana C. Garofalo,Dina A. Balderes,Lori Sussel,Kenneth P. Olive,Raul Rabadan +11 more
TL;DR: The findings indicate that lncRNAs are associated with genetic marks of pancreatic cancer risk, contribute to the transcriptional regulation of neoplastic cells and provide an important resource to design functional studies of lnc RNAs in PDA.
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Noninvasive Young's modulus visualization of fibrosis progression and delineation of pancreatic ductal adenocarcinoma (PDAC) tumors using Harmonic Motion Elastography (HME) in vivo.
Alireza Nabavizadeh,Thomas Payen,Alina Iuga,Irina Sagalovskiy,Deborah D. Desrouilleres,Niloufar Saharkhiz,Carmine F. Palermo,Stephen A. Sastra,Paul E. Oberstein,Vilma L. Rosario,Michael D. Kluger,Beth Schrope,John A. Chabot,Kenneth P. Olive,Elisa E. Konofagou +14 more
TL;DR: HME, a quantitative ultrasound-based imaging method, was applied to calculate Young's modulus (YM) in PDAC mouse models and human pancreatic resection specimens of PDAC to develop a non-invasive, quantitative imaging tool for detecting, staging and delineating PDAC tumor margins based on the change in collagen density.
Journal ArticleDOI
Harmonic Motion Imaging of Pancreatic Tumor Stiffness Indicates Disease State and Treatment Response.
Thomas Payen,Paul E. Oberstein,Niloufar Saharkhiz,Carmine F. Palermo,Stephen A. Sastra,Yang Han,Alireza Nabavizadeh,Irina Sagalovskiy,Barbara Orelli,Vilma L. Rosario,Deborah D. Desrouilleres,Helen Remotti,Michael D. Kluger,Beth Schrope,John A. Chabot,Alina Iuga,Elisa E. Konofagou,Kenneth P. Olive +17 more
TL;DR: The findings of this study support further development of HMI for clinical applications in disease staging and treatment response assessment in PDA.
Journal ArticleDOI
Effective Delivery of a Microtubule Polymerization Inhibitor Synergizes with Standard Regimens in Models of Pancreatic Ductal Adenocarcinoma.
Jaime A. Eberle-Singh,Irina Sagalovskiy,H. Carlo Maurer,Stephen A. Sastra,Carmine F. Palermo,Amanda R. Decker,Min Jung Kim,Josephine Sheedy,Anna Mollin,Liangxian Cao,Jianhua Hu,Arthur Branstrom,Marla Weetall,Kenneth P. Olive +13 more
TL;DR: Clear rationale for the development of PTC596 in combination with standard-of-care chemotherapy for PDA is demonstrated, with pharmacologic properties that overcome the barrier to drug delivery in PDA, including a long circulating half-life, lack of P-glycoprotein substrate activity, and high systemic tolerability.