Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nancy Y. Ip,Carlos F. Ibáñez,Steven H. Nye,Joyce McClain,Pamela F. Jones,David R. Gies,Leonardo Belluscio,M M Le Beau,R. Espinosa,Stephen P. Squinto +9 more
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TLDR
A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.Abstract:
Nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) are the three members of the neurotrophin family known to exist in mammals. Recently, a fourth neurotrophin (designated neurotrophin-4 or NT-4), which shares all of the features found in the mammalian neurotrophins, has been identified in Xenopus and viper. We used sequences specific to the Xenopus/viper NT-4 to isolate a neurotrophin from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4. Human NT-4 as well as a human NT-4 pseudogene colocalize to chromosome 19 band q13.3. Mammalian NT-4 has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophins. However, mammalian NT-4 displays bioactivity and trk receptor specificity similar to that of Xenopus NT-4.read more
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Brain-derived Neurotrophic Factor
TL;DR: Since the purification of BDNF in 1982, a great deal of evidence has mounted for its central roles in brain development, physiology, and pathology, and application of the trophic properties ofBDNF may lead to novel therapeutic options in neurodegenerative diseases and perhaps even in neuropsychiatric disorders.
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Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
TL;DR: It is demonstrated that BDNF and NT-3 are stress-responsive genes and the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus is raised.
Journal ArticleDOI
Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
TL;DR: It is now apparent that regulation of neuronal function by the recently identified members of the neurotrophin family is far more complex than envisioned on the basis of work with NGF, particularly for neurons in the central nervous system (CNS).
Journal ArticleDOI
Neurotrophins regulate dendritic growth in developing visual cortex
TL;DR: The spectrum of neurotrophic actions and the laminar specificity of these actions implicate endogenous neurotrophins as regulatory signals in the development of specific dendritic patterns in mammalian neocortex.
Journal ArticleDOI
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Tõnis Timmusk,Tõnis Timmusk,Kaia Palm,Kaia Palm,Madis Metsis,Madis Metsis,Tõnu Reintam,Viiu Paalme,Mart Saarma,Mart Saarma,Håkan Persson +10 more
TL;DR: The data demonstrate that alternative usage of four promoters within the BDNF gene and differential splicing control tissue-specific and seizure-induced expression of BDNF mRNA.
References
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Journal ArticleDOI
Molecular cloning and expression of brain-derived neurotrophic factor.
Joachim Leibrock,Friedrich Lottspeich,Hohn Andreas,Magdalena Hofer,Bastian Hengerer,Piotr Masiakowski,Hans Thoenen,Yves-Alain Barde +7 more
TL;DR: The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally.
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The trk proto-oncogene product: a signal transducing receptor for nerve growth factor
TL;DR: Affinity cross-linking and equilibrium binding experiments with 125I-labeled NGF indicate that p140prototrk binds NGF specifically in cultured cells with a dissociation constant of 10(-9) molar.
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The trk proto-oncogene encodes a receptor for nerve growth factor.
TL;DR: The results indicate that gp140trk is a functional NGF receptor that mediates at least some of the signal transduction processes initiated by this neurotrophic factor.
Journal ArticleDOI
Neurotrophin-3: a neurotrophic factor related to NGF and BDNF
Maisonpierre Peter C,Leonardo Belluscio,Stephen P. Squinto,Nancy Y. Ip,Mark E. Furth,Ronald M. Lindsay,George D. Yancopoulos +6 more
TL;DR: The distribution of NT-3 messenger RNA and its biological activity on a variety of neuronal populations clearly distinguishNT-3 from NGF and BDNF, and provide compelling evidence that NT- 3 is an authentic neurotrophic factor that has its own characteristic role in vivo.
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NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression.
Maisonpierre Peter C,Leonardo Belluscio,Beth Friedman,Ralph F. Alderson,Stanley J. Wiegand,Mark E. Furth,Ronald M. Lindsay,George D. Yancopoulos +7 more
TL;DR: The observations are consistent with the idea that NT-3, BDNF, and NGF have paralleled as well as reciprocal roles in vivo, and do share one striking similarity--high level expression in the adult hippocampus.