D
David R. Gies
Researcher at Regeneron
Publications - 8
Citations - 2896
David R. Gies is an academic researcher from Regeneron. The author has contributed to research in topics: Receptor tyrosine kinase & Neuromuscular junction. The author has an hindex of 7, co-authored 8 publications receiving 2824 citations.
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Journal ArticleDOI
The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
Trevor Stitt,Greg Conn,Martin Goret,Martin Goret,Cary Lai,Joanne Bruno,Czeslaw Radzlejewski,Karen Mattsson,John Fisher,David R. Gies,Pamela F. Jones,Piotr Masiakowski,Terence E Ryan,Nancy J Tobkes,D.H Chen,Peter S. DiStefano,George L. Long,Claudio Basilico,Mitchell Goldfarb,Greg Lemke,David J. Glass,George D. Yancopoulos +21 more
TL;DR: The identification of ligands for Tyro 3 and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases, correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related toprotein S but lacking any known function.
Journal ArticleDOI
Agrin Acts via a MuSK Receptor Complex
David J. Glass,David C. Bowen,Trevor Stitt,Czeslaw Radziejewski,Joanne Bruno,Terence E Ryan,David R. Gies,Sonal Shah,Karen Mattsson,Steven J. Burden,Peter S. DiStefano,David M. Valenzuela,Thomas M. DeChiara,George D. Yancopoulos +13 more
TL;DR: It is demonstrated that agrin acts via a receptor complex that includes MuSK as well as a myotube-specific accessory component, which is a receptor tyrosine kinase localized to the motor endplate.
Journal ArticleDOI
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Nancy Y. Ip,Carlos F. Ibáñez,Steven H. Nye,Joyce McClain,Pamela F. Jones,David R. Gies,Leonardo Belluscio,M M Le Beau,R. Espinosa,Stephen P. Squinto +9 more
TL;DR: A neurotrophin is isolated from both human and rat genomic DNA that appears to represent the mammalian counterpart of Xenopus/viper NT-4, which has many unusual features compared to the previously identified neurotrophins and is less conserved evolutionarily than the other neurotrophs.
Journal ArticleDOI
Receptor tyrosine kinase specific for the skeletal muscle lineage: Expression in embryonic muscle, at the neuromuscular junction, and after injury
David M. Valenzuela,Trevor Stitt,Peter S. DiStefano,Rojas Eduardo A,Karen Mattsson,Debra L Compton,Lorna Nunez,John S. Park,Jennifer L. Stark,David R. Gies,Susan Thomas,Michelle M. Le Beau,Anthony A. Fernald,Neal G. Copeland,Nancy A. Jenkins,Steven J. Burden,David J. Glass,George D. Yancopoulos +17 more
TL;DR: Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function.
Journal ArticleDOI
Alternative forms of rat TrkC with different functional capabilities
David M. Valenzuela,Maisonpierre Peter C,David J. Glass,Rojas Eduardo A,Lorna Nunez,Yuan Kong,David R. Gies,Trevor Stitt,Nancy Y. Ip,George D. Yancopoulos +9 more
TL;DR: This paper identified transcripts encoding several different forms of rat TrkC, a member of the Trk family of receptor tyrosine kinases that serves as a receptor for neurotrophin-3.