S
Steve Jones
Researcher at University of British Columbia
Publications - 2
Citations - 751
Steve Jones is an academic researcher from University of British Columbia. The author has contributed to research in topics: Null cell & Neural stem cell. The author has an hindex of 2, co-authored 2 publications receiving 577 citations.
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Journal ArticleDOI
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
Journal ArticleDOI
In vitro modeling of glioblastoma initiation using PDGF-AA and p53-null neural progenitors.
Alexandra Bohm,Jessica DePetro,Carmen Binding,Amanda Gerber,Nicholas Chahley,N Dan Berger,Mathaeus Ware,Kaitlin Thomas,U Senapathi,Shazreh Bukhari,Cindy Chen,Erin Chahley,Cameron Grisdale,Sam Lawn,Yaping Yu,Raymond C B Wong,Yaoqing Shen,Hiba Omairi,Reza Mirzaei,Nourah Alshatti,Haley Pedersen,Wee Yong,Samuel Weiss,Jennifer A. Chan,Patrick J. Cimino,John Kelly,Steve Jones,Eric C. Holland,Michael D. Blough,Gregory Cairncross +29 more
TL;DR: This model associates genome instability in neural progenitor cells with chronic exposure to PDGF-AA, is the first to approximate the genomic landscape of human GBM, and the first in which the earliest phases of the disease can be studied directly.