Y
Young Ho Ahn
Researcher at Seoul National University
Publications - 40
Citations - 2036
Young Ho Ahn is an academic researcher from Seoul National University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 23 publications receiving 1735 citations. Previous affiliations of Young Ho Ahn include Keimyung University & UPRRP College of Natural Sciences.
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Journal ArticleDOI
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
Journal ArticleDOI
Adiponectin Increases Fatty Acid Oxidation in Skeletal Muscle Cells by Sequential Activation of AMP-Activated Protein Kinase, p38 Mitogen-Activated Protein Kinase, and Peroxisome Proliferator–Activated Receptor α
TL;DR: It is suggested that adiponectin stimulates fatty acid oxidation in muscle cells by the sequential activation of AMPK, p38 MAPK, and PPARα.
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CXCR2 Expression in Tumor Cells Is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma
Pierre Saintigny,Erminia Massarelli,Steven H. Lin,Young Ho Ahn,Yulong Chen,Sangeeta Goswami,Baruch Erez,Michael S. O'Reilly,Diane Liu,J. Jack Lee,Li Zhang,Yuan Ping,Carmen Behrens,Luisa M. Solis Soto,John V. Heymach,Edward S. Kim,Roy S. Herbst,Scott M. Lippman,Ignacio I. Wistuba,Waun Ki Hong,Jonathan M. Kurie,Ja Seok Koo +21 more
TL;DR: The CXCR2 axis may be an important target in smoking-related lung adenocarcinoma and the role of CX CR2 and its ligands in lung cancer cells is examined.
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N-Methyl-D-aspartate receptor blockade induces neuronal apoptosis in cortical culture.
TL;DR: The present results demonstrate that NMDA antagonists induce neuronal apoptosis in cortical culture, consistent with the findings obtained in immature rats.
Journal ArticleDOI
Depletion of Intracellular Zinc Induces Protein Synthesis-Dependent Neuronal Apoptosis in Mouse Cortical Culture
TL;DR: It is suggested that redistribution of zinc from intracellular to extracellular space may synergistically contribute to neuronal apoptosis in AD.