W
Wei Lin
Researcher at University of Texas MD Anderson Cancer Center
Publications - 11
Citations - 1578
Wei Lin is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Metastasis & Adenocarcinoma. The author has an hindex of 6, co-authored 8 publications receiving 1350 citations. Previous affiliations of Wei Lin include University of Texas Health Science Center at Houston.
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Journal ArticleDOI
Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression
Limo Chen,Don L. Gibbons,Sangeeta Goswami,Maria Angelica Cortez,Young Ho Ahn,Lauren Averett Byers,Xuejun Zhang,Xiaohui Yi,David Dwyer,Wei Lin,Lixia Diao,Jing Wang,Jonathon D. Roybal,Mayuri Patel,Christin Ungewiss,David H. Peng,Scott J. Antonia,Melanie Mediavilla-Varela,Gordon Robertson,Steve Jones,Milind Suraokar,James W. Welsh,Baruch Erez,Ignacio I. Wistuba,Lieping Chen,Di Peng,Shanshan Wang,Stephen E. Ullrich,John V. Heymach,Jonathan M. Kurie,F. Xiao Feng Qin,F. Xiao Feng Qin +31 more
TL;DR: A molecular link between epithelial-to-mesenchymal transition (EMT) and CD8+ TIL immunosuppression and cancer progression is demonstrated and ZEB1 promotes metastasis through a heretofore unappreciated cell non-autonomous mechanism, and subgroups of patients in whom malignant progression is driven by EMT activators may respond to treatment with PD-L1 antagonists.
Journal ArticleDOI
Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression
Don L. Gibbons,Wei Lin,Chad J. Creighton,Zain H. Rizvi,Philip A. Gregory,Gregory J. Goodall,Nishan Thilaganathan,Liqin Du,Yiqun Zhang,Alexander Pertsemlidis,Jonathan M. Kurie +10 more
TL;DR: It is concluded that tumor cell metastasis is regulated by miR-200 expression, which changes in response to contextual extracellular cues, which decreased during EMT.
Journal ArticleDOI
The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200–dependent pathway in mice
Yanan Yang,Young Ho Ahn,Don L. Gibbons,Yi Zang,Wei Lin,Nishan Thilaganathan,Cristina A. Alvarez,Daniel C. Moreira,Chad J. Creighton,Philip A. Gregory,Gregory J. Goodall,Jonathan M. Kurie +11 more
TL;DR: What is believed to be a novel Jagged2/miR-200-dependent pathway that mediates lung adenocarcinoma EMT and metastasis in mice is revealed and may have implications for the treatment of human epithelial tumors.
Journal ArticleDOI
Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma.
Don L. Gibbons,Wei Lin,Chad J. Creighton,Shuling Zheng,Dror Berel,Yanan Yang,Maria Gabriela Raso,Diane D. Liu,Ignacio I. Wistuba,Guillermina Lozano,Jonathan M. Kurie +10 more
TL;DR: Evidence that K-rasG12D; p53R172H mice recapitulate features of human NSCLC metastasis is provided and will provide a useful platform on which to study the biologic basis for lung adenocarcinoma metastasis and its prevention by novel agents is studied.
Journal ArticleDOI
Map2k4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing Peroxisome Proliferator-Activated Receptor γ2 Expression
Young Ho Ahn,Yanan Yang,Don L. Gibbons,Chad J. Creighton,Fei Yang,Ignacio I. Wistuba,Wei Lin,Nishan Thilaganathan,Cristina A. Alvarez,Jonathon D. Roybal,Elizabeth J. Goldsmith,Cathy Tournier,Jonathan M. Kurie +12 more
TL;DR: It is concluded that Map2k4 functions as a tumor suppressor in lung adenocarcinoma and inhibits tumor cell invasion by decreasing PPARγ2 levels.