J
Jack F. Youngren
Researcher at University of California, San Francisco
Publications - 67
Citations - 5334
Jack F. Youngren is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Insulin receptor & Insulin. The author has an hindex of 34, co-authored 66 publications receiving 4536 citations. Previous affiliations of Jack F. Youngren include University of British Columbia & University of San Francisco.
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Journal ArticleDOI
Plasma Adiponectin Concentration Is Associated With Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans
Norbert Stefan,Barbora Vozarova,Tohru Funahashi,Yuji Matsuzawa,Christian Weyer,Robert S. Lindsay,Jack F. Youngren,Peter J. Havel,Richard E. Pratley,Clifton Bogardus,P. Antonio Tataranni +10 more
TL;DR: The cross-sectional data suggest a role of physiological concentration of fasting plasma adiponectin in the regulation of skeletal muscle IR tyrosine phosphorylation and indicate that adiponECTin plays an important role in regulation of insulin sensitivity in humans.
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Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.
David A. Quigley,Ha X. Dang,Shuang G. Zhao,Paul Lloyd,Rahul Aggarwal,Joshi J. Alumkal,Adam Foye,Vishal Kothari,Marc D. Perry,Adina M. Bailey,Denise Playdle,Travis J. Barnard,Li Zhang,Jin Zhang,Jack F. Youngren,Marcin Cieslik,Abhijit Parolia,Tomasz M. Beer,George Thomas,Kim N. Chi,Martin E. Gleave,Nathan A. Lack,Amina Zoubeidi,Robert E. Reiter,Robert E. Reiter,Matthew Rettig,Owen N. Witte,Charles J. Ryan,Lawrence Fong,Won Kim,Terence W. Friedlander,Jonathan Chou,Haolong Li,Rajdeep Das,Hui Li,Ruhollah Moussavi-Baygi,Hani Goodarzi,Luke A. Gilbert,Primo N. Lara,Christopher P. Evans,Theodore C. Goldstein,Theodore C. Goldstein,Joshua M. Stuart,Scott A. Tomlins,Daniel E. Spratt,R. Keira Cheetham,Donavan T. Cheng,Kyle Kai-How Farh,Julian S. Gehring,Jörg Hakenberg,Arnold Liao,P. G. Febbo,John Shon,Brad Sickler,Serafim Batzoglou,Karen E. Knudsen,Housheng Hansen He,Jiaoti Huang,Alexander W. Wyatt,Scott M. Dehm,Alan Ashworth,Arul M. Chinnaiyan,Christopher G. Maher,Eric J. Small,Felix Y. Feng +64 more
TL;DR: Integrative deep whole-genome and -transcriptome analysis of 101 castration-resistant prostate cancer metastases identified structural variants altering critical regulators of tumorigenesis and progression not detectable by exome approaches, providing a comprehensive view of how structural variations affect critical regulators in metastatic prostate cancer.
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Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study
Rahul Aggarwal,Jiaoti Huang,Joshi J. Alumkal,Li Zhang,Felix Y. Feng,George Thomas,Alana S. Weinstein,Verena Friedl,Can Zhang,Owen N. Witte,Paul Lloyd,Martin E. Gleave,Christopher P. Evans,Jack F. Youngren,Tomasz M. Beer,Matthew Rettig,Christopher K. Wong,Lawrence D. True,Adam Foye,Denise Playdle,Charles J. Ryan,Primo N. Lara,Kim N. Chi,Vlado Uzunangelov,Artem Sokolov,Yulia Newton,Himisha Beltran,Francesca Demichelis,Mark A. Rubin,Joshua M. Stuart,Eric J. Small +30 more
TL;DR: The near-mutual exclusivity with DNA repair alterations suggests t-SCNC may be a distinct subset of mCRPC, and transcriptional profiling facilitates the identification of t- SCNC and novel therapeutic targets.
Journal ArticleDOI
Androgen receptor gene aberrations in circulating cell-free DNA: biomarkers of therapeutic resistance in castration-resistant prostate cancer
Arun Azad,Stanislav Volik,Alexander W. Wyatt,Anne Haegert,Stephane Le Bihan,Robert H. Bell,Shawn Anderson,Brian McConeghy,Robert Shukin,Jenny Bazov,Jack F. Youngren,Pamela L. Paris,George Thomas,Eric J. Small,Yuzhuo Wang,Yuzhuo Wang,Martin E. Gleave,Martin E. Gleave,Colin Collins,Colin Collins,Kim N. Chi,Kim N. Chi +21 more
TL;DR: The data illustrate that genomic analysis of cfDNA is a minimally invasive method for interrogating mechanisms of therapeutic resistance in mCRPC and suggest that novel agents targeting the androgen–androgen receptor (AR) axis have altered the treatment paradigm.
Journal ArticleDOI
Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus.
Betty A. Maddux,Paolo Sbraccia,S Kumakura,Shlomo Sasson,Jack F. Youngren,A Fisher,Steven A. Spencer,Andrew Grupe,William J. Henzel,Timothy A. Stewart +9 more
TL;DR: It is found that PC-1 activity is increased in fibroblasts from seven of nine patients with typical non-insulin-dependent diabetes mellitus, and overexpression of PC- 1 in transfected cultured cells reduces insulin-stimulated tyrosine kinase activity.