T
Timothy A. Stewart
Researcher at Genentech
Publications - 98
Citations - 10208
Timothy A. Stewart is an academic researcher from Genentech. The author has contributed to research in topics: Nucleic acid & Genetically modified mouse. The author has an hindex of 35, co-authored 98 publications receiving 9920 citations.
Papers
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Journal ArticleDOI
Multiple defects of immune cell function in mice with disrupted interferon-gamma genes
TL;DR: IFN-gamma is essential for the function of several cell types of the murine immune system and has impaired production of macrophage antimicrobial products and reduced expression of Macrophage major histocompatibility complex class II antigens.
Patent
Secreted and Transmembrane Polypeptides and Nucleic Acids Encoding the Same
Kevin P. Baker,Maureen Beresini,Laura DeForge,Luc Desnoyers,Ellen Filvaroff,Wei-Qiang Gao,Mary E. Gerritsen,Audrey Goddard,Paul J. Godowski,Austin L. Gurney,Steven Sherwood,Victoria Smith,Timothy A. Stewart,Daniel Tumas,Colin K. Watanabe,William I. Wood,Zemin Zhang +16 more
TL;DR: In this paper, the present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polyptides, and vectors and host cells comprising those nucleic amino acid sequences.
Journal ArticleDOI
IGF-I is required for normal embryonic growth in mice.
Lyn Powell-Braxton,P Hollingshead,C Warburton,M Dowd,Sharon Pitts-Meek,D Dalton,N Gillett,Timothy A. Stewart +7 more
TL;DR: IGF-I appears to be essential for correct embryonic development in mice and is reported to affect linear growth, glucose metabolism, organ homeostasis, and the immune and neurologic systems.
Journal ArticleDOI
Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.
Elizabeth Tomlinson,Ling Fu,Linu M. John,Bruce Hultgren,Xiaojian Huang,Mark Renz,Jean Philippe Stephan,Saio Ping Tsai,Lyn Powell-Braxton,Dorothy French,Timothy A. Stewart +10 more
TL;DR: It is reported that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure and did not become obese or diabetic on a high fat diet.
Journal ArticleDOI
Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice.
Marie-Laure Santiago-Raber,Roberto Baccala,Katarina M. Haraldsson,Divaker Choubey,Timothy A. Stewart,Dwight H. Kono,Argyrios N. Theofilopoulos +6 more
TL;DR: The data indicate that type-I IFNs are important mediators in the pathogenesis of murine lupus, and that reducing their activity in the human counterpart may be beneficial.