S
Steven L. Wagner
Researcher at University of California
Publications - 9
Citations - 2104
Steven L. Wagner is an academic researcher from University of California. The author has contributed to research in topics: Gene knockdown & Presenilin. The author has an hindex of 7, co-authored 9 publications receiving 2016 citations. Previous affiliations of Steven L. Wagner include Veterans Health Administration & Harvard University.
Papers
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
Journal ArticleDOI
Activating transcription factor-1 can mediate Ca(2+)- and cAMP-inducible transcriptional activation.
TL;DR: It is reported that one member of this family, ATF-1, can mediate both Ca2+ and cAMP transcriptional responses, but that the responses to the two pathways differ in magnitude.
Journal ArticleDOI
Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Aβ Secretion
Mikko Hiltunen,Alice Lu,Anne V. Thomas,Donna M. Romano,Minji Kim,Phill Jones,Zhongcong Xie,Maria Z. Kounnas,Steven L. Wagner,Oksana Berezovska,Bradley T. Hyman,Giuseppina Tesco,Lars Bertram,Rudolph E. Tanzi +13 more
TL;DR: It is suggested that UBQLN1 may normally serve as a cytoplasmic “gatekeeper” that may control APP trafficking from intracellular compartments to the cell surface, thereby influencing the generation of Aβ.
Patent
Method of diagnosis of amyloidoses
TL;DR: In this paper, the level of immunoreactivity toward a monoclonal antibody raised against native PN-2/βAPP or other amyloid precursor protein in the sample is measured, and this measured level is compared to the antibody in a sample from
Patent
Purification, detection and methods of use of protease nexin-2
TL;DR: In this paper, the use of immunopurification of Protease Nexin-2 and β amyloid precursor protein is discussed and used in the diagnosis of Alzheimer's disease and other conditions.