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Steven Rakar
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 16
Citations - 1399
Steven Rakar is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Signal transduction & SOCS3. The author has an hindex of 10, co-authored 16 publications receiving 1354 citations.
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Journal ArticleDOI
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Andrew W. Roberts,Lorraine Robb,Steven Rakar,Lynne Hartley,Leonie A. Cluse,Nicos A. Nicola,Donald Metcalf,Douglas J. Hilton,Warren S. Alexander +8 more
TL;DR: The data suggest that SOCS3 is required for placental development but dispensable for normal hematopoiesis in the mouse embryo.
Journal ArticleDOI
Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction.
Douglas J. Hilton,Adrienne A. Hilton,A Raicevic,Steven Rakar,M. Harrison-Smith,Nicholas M. Gough,C G Begley,D. Metcalf,Nicos A. Nicola,Tracy A. Willson +9 more
TL;DR: The capacity to bind IL‐11 with high affinity appeared to require coexpression of both NR1 and gp130, the common subunit of the IL‐6, leukaemia inhibitory factor (LIF), oncostatin M (OSM) and ciliary neurotrophic factor (CNTF) receptors.
Journal ArticleDOI
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo.
Jian-Guo Zhang,Donald Metcalf,Steven Rakar,Maria Asimakis,Christopher J. Greenhalgh,Tracy A. Willson,Robyn Starr,Sandra E. Nicholson,W M Carter,Warren S. Alexander,Douglas J. Hilton,Nicos A. Nicola +11 more
TL;DR: It is demonstrated that deletion of the SOCS box leads to a partial loss of function of SOCS-1, an essential physiological inhibitor of IFN-γ signaling.
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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Danielle L. Krebs,Rachel T Uren,Donald Metcalf,Steven Rakar,Jian-Guo Zhang,Robyn Starr,David P De Souza,Kathy Hanzinikolas,Jo L. Eyles,Lisa M. Connolly,Richard J. Simpson,Nicos A. Nicola,Sandra E. Nicholson,Manuel Baca,Douglas J. Hilton,Warren S. Alexander +15 more
TL;DR: SOCS-6 binds to elongins B and C through its SOCS box, suggesting that it might act as an E3 ubiquitin ligase that targets proteins bound to its SH2 domain for ubiquitination and proteasomal degradation.
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Suppressors of cytokine signaling (SOCS): Negative regulators of signal transduction
Warren S. Alexander,Robyn Starr,Donald Metcalf,Sandra E. Nicholson,Alison Farley,Andrew G. Elefanty,Marta Brysha,Benjamin T. Kile,Rachel Richardson,Manuel Baca,Jian-Guo Zhang,Tracy A. Willson,Elizabeth M. Viney,Naomi S. Sprigg,Steven Rakar,Jason Corbin,Sandra Mifsud,Ladina DiRago,Dale Cary,Nicos A. Nicola,Douglas J. Hilton +20 more
TL;DR: It is proposed that the absence of SOCS‐1 in these mice prevents lymphocytes and liver cells from appropriately controlling signals from cytokines with cytotoxic side effects.