A
Antonio de Marvao
Researcher at Imperial College London
Publications - 94
Citations - 4448
Antonio de Marvao is an academic researcher from Imperial College London. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 25, co-authored 80 publications receiving 3062 citations. Previous affiliations of Antonio de Marvao include Medical Research Council & University of Paris.
Papers
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Journal ArticleDOI
Anatomically Constrained Neural Networks (ACNNs): Application to Cardiac Image Enhancement and Segmentation
Ozan Oktay,Enzo Ferrante,Konstantinos Kamnitsas,Mattias P. Heinrich,Wenjia Bai,Jose Caballero,Stuart A. Cook,Antonio de Marvao,Timothy J W Dawes,Declan P. O'Regan,Bernhard Kainz,Ben Glocker,Daniel Rueckert +12 more
TL;DR: In this article, a generic training strategy that incorporates anatomical prior knowledge into CNNs through a new regularization model, which is trained end-to-end, encourages models to follow the global anatomical properties of the underlying anatomy via learnt non-linear representations of the shape.
Journal ArticleDOI
Anatomically Constrained Neural Networks (ACNN): Application to Cardiac Image Enhancement and Segmentation
Ozan Oktay,Enzo Ferrante,Konstantinos Kamnitsas,Mattias P. Heinrich,Wenjia Bai,Jose Caballero,Stuart A. Cook,Antonio de Marvao,Timothy J W Dawes,Declan P. O'Regan,Bernhard Kainz,Ben Glocker,Daniel Rueckert +12 more
TL;DR: This work proposes a generic training strategy that incorporates anatomical prior knowledge into CNNs through a new regularisation model, which is trained end-to-end and demonstrates how the learnt deep models of 3-D shapes can be interpreted and used as biomarkers for classification of cardiac pathologies.
Journal ArticleDOI
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease
Angharad M. Roberts,Angharad M. Roberts,James S. Ware,Daniel S. Herman,Daniel S. Herman,Daniel S. Herman,Sebastian Schafer,John Baksi,Alexander G. Bick,Alexander G. Bick,Rachel Buchan,Roddy Walsh,Shibu John,S Wilkinson,Francesco Mazzarotto,Francesco Mazzarotto,Leanne E. Felkin,Leanne E. Felkin,Sungsam Gong,Jacqueline A. L. MacArthur,Fiona Cunningham,Jason Flannick,Jason Flannick,Stacey Gabriel,David Altshuler,David Altshuler,Peter S. Macdonald,Peter S. Macdonald,Peter S. Macdonald,Matthias Heinig,Anne Keogh,Anne Keogh,Anne Keogh,Christopher S. Hayward,Christopher S. Hayward,Christopher S. Hayward,Nicholas R. Banner,Nicholas R. Banner,Dudley J. Pennell,Dudley J. Pennell,Declan P. O'Regan,Tan Ru San,Antonio de Marvao,Timothy J W Dawes,Ankur Gulati,Emma J. Birks,Emma J. Birks,Magdi H. Yacoub,Michael H. Radke,Michael Gotthardt,James G. Wilson,Christopher J. O'Donnell,Sanjay K Prasad,Paul J.R. Barton,Paul J.R. Barton,Diane Fatkin,Diane Fatkin,Diane Fatkin,Norbert Hubner,Norbert Hubner,Jonathan G. Seidman,Christine E. Seidman,Stuart A. Cook +62 more
TL;DR: It is shown that TTNtv is the most common genetic cause of DCM in ambulant patients in the community, identify clinically important manifestations ofTTNtv-positive DCM, and define the penetrance and outcomes of TTNTV in the general population.
Book ChapterDOI
Cardiac image super-resolution with global correspondence using multi-atlas patchmatch.
Wenzhe Shi,Jose Caballero,Christian Ledig,Xiahai Zhuang,Wenjia Bai,Kanwal K. Bhatia,Antonio de Marvao,Timothy J W Dawes,Declan P. O'Regan,Daniel Rueckert +9 more
TL;DR: A novel algorithm for the estimation of high-resolution cardiac MR images from single short-axis cardiac MR image stacks using an innovative super-resolution model which does not require explicit motion estimation and can be used for the reproducible estimation of 3D cardiac functional indices.
Journal ArticleDOI
Titin-truncating variants affect heart function in disease cohorts and the general population
Sebastian Schafer,Antonio de Marvao,Eleonora Adami,Lorna R. Fiedler,Benjamin Ng,Ester Khin,Owen J. L. Rackham,Sebastiaan van Heesch,Chee Jian Pua,Miao Kui,Roddy Walsh,Upasana Tayal,Sanjay K Prasad,Timothy J W Dawes,Nicole S. J. Ko,David Sim,Laura Lihua Chan,Calvin W. L. Chin,Francesco Mazzarotto,Paul J.R. Barton,Franziska Kreuchwig,Dominique P.V. de Kleijn,Dominique P.V. de Kleijn,Teresa Totman,Carlo Biffi,Nicole Tee,Daniel Rueckert,Valentin Schneider,Allison Faber,Vera Regitz-Zagrosek,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Wolfgang A. Linke,Jean-Paul Kovalik,Declan P. O'Regan,James S. Ware,James S. Ware,Norbert Hubner,Norbert Hubner,Stuart A. Cook,Stuart A. Cook +42 more
TL;DR: Data show that TTNtv have molecular and physiological effects on the heart across species, with a continuum of expressivity in health and disease, and are associated with eccentric cardiac remodeling in healthy humans.