S
Su Yang
Researcher at Beckman Research Institute
Publications - 9
Citations - 1359
Su Yang is an academic researcher from Beckman Research Institute. The author has contributed to research in topics: Neural stem cell & Stem cell. The author has an hindex of 8, co-authored 9 publications receiving 1243 citations. Previous affiliations of Su Yang include City of Hope National Medical Center.
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Journal ArticleDOI
MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling
TL;DR: Let-7b establishes an efficient strategy to control neural stem cell proliferation and differentiation by targeting the stem cell regulator TLX and the cell cycle regulator cyclin D1.
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Orphan nuclear receptor TLX activates Wnt/beta-catenin signalling to stimulate neural stem cell proliferation and self-renewal.
Qiuhao Qu,Guoqiang Sun,Wen-Wu Li,Su Yang,Peng Ye,Chunnian Zhao,Ruth T. Yu,Fred H. Gage,Ronald M. Evans,Yanhong Shi +9 more
TL;DR: The hypothesis that TLX acts through the Wnt/β-catenin pathway to regulate neural stem cell proliferation and self-renewal is supported and this study suggests that neural stem cells can promote their own self-Renewal by secreting signalling molecules that act in an autocrine/paracrine mode.
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Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation
TL;DR: A novel role for LSD1 is revealed in neural stem cells proliferation and a mechanism for neural stem cell proliferation is uncovered through recruitment of LSD1 to modulate TLX activity is uncovered.
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Nuclear Receptor TLX Regulates Cell Cycle Progression in Neural Stem Cells of the Developing Brain
TL;DR: It is shown that TLX is expressed specifically in periventricular neural stem cells in embryonic brains, and transient knockdown of TLX by in utero electroporation led to precocious cell cycle exit and differentiation of Neural stem cells followed by outward migration.
Journal ArticleDOI
Genome-wide profiling identified a set of miRNAs that are differentially expressed in glioblastoma stem cells and normal neural stem cells.
Ming-Fei Lang,Su Yang,Chunnian Zhao,Guoqiang Sun,Kiyohito Murai,Xiwei Wu,Jinhui Wang,Hanlin Gao,Christine E. Brown,Xiaoxuan Liu,Jiehua Zhou,Ling Peng,John J. Rossi,Yanhong Shi +13 more
TL;DR: Characterizing the role of these miRNAs in glioblastoma stem cells may lead to the development of miRNA-based therapies that specifically target tumor stem cells, but spare normal stem cells.