Suchira Bose

TL;DR: A novel in vivo model of tau propagation using human P301S tau transgenic mice infused unilaterally with brain extract containing tau aggregates is described and the rapid and robust propagation of t Tau pathology in this model will be valuable for both basic research and the drug discovery process.

TL;DR: It is shown that seeding is conferred by aggregated Tau that enters cells through macropinocytosis and seeds the assembly of endogenous Tau into filaments, and conformational differences between native and synthetic Tau aggregates that may account for the higher seeding activity of native assembled Tau.

TL;DR: A range of filamentous tau aggregates are the major species that underlie the spreading of tau pathology in the P301S transgenic model, and it is shown that seed-competent tau species comprise small fibrils capable of seeding t Tau pathology in cell and animal models.

TL;DR: GSK3α, GSK3β, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes associated with AD.

TL;DR: It is suggested that nicotinic acetylcholine receptor subunits may be involved in the modulation of cerebellar activity as well as developmental and age-related disorders.