J
John N. Calley
Researcher at Eli Lilly and Company
Publications - 26
Citations - 998
John N. Calley is an academic researcher from Eli Lilly and Company. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 14, co-authored 26 publications receiving 820 citations.
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Journal ArticleDOI
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Solveig K. Sieberts,Thanneer M. Perumal,Minerva M. Carrasquillo,Mariet Allen,Joseph S. Reddy,Gabriel E. Hoffman,Kristen K. Dang,John N. Calley,Phillip J. Ebert,James A. Eddy,Xue Wang,Anna K. Greenwood,Sara Mostafavi,Sara Mostafavi,S Akbarian,J Bendl,M S Breen,K Brennand,L Brown,A Browne,J D Buxbaum,A Charney,Andrew Chess,Couto L,Gregory E. Crawford,Devillers O,Bernie Devlin,Amanda Dobbyn,E Domenici,M Filosi,E Flatow,Nancy Francoeur,John F. Fullard,S E Gil,Kiran Girdhar,A Gulyás-Kovács,R.E. Gur,C G Hahn,Vahram Haroutunian,Mads E. Hauberg,Laura M. Huckins,Rivka Jacobov,Y Jiang,Jessica S. Johnson,Bibi Kassim,Y Kim,Lambertus Klei,Robin Kramer,Mario Lauria,Thomas Lehner,David A. Lewis,Barbara K. Lipska,Kelsey S. Montgomery,R Park,C Rosenbluh,Panagiotis Roussos,Douglas M. Ruderfer,G Senthil,Hardik Shah,Laura G. Sloofman,L Song,E Stahl,P.F. Sullivan,R Visintainer,J Wang,Y C Wang,Jennifer Wiseman,E Xia,W Zhang,Elizabeth Zharovsky,L Addis,S N Addo,David C. Airey,Matthias Arnold,David A. Bennett,Y Bi,K Biber,Colette Blach,E Bradhsaw,Paul Brennan,R Canet-Aviles,S Cao,A Cavalla,Yooree Chae,W W Chen,J Cheng,David A. Collier,J L Dage,Eric B. Dammer,J W Davis,John B. Davis,Derek Drake,D Duong,Brian J. Eastwood,Michelle E. Ehrlich,B Ellingson,B W Engelmann,S Esmaeelinieh,Daniel Felsky,Cory C. Funk,Chris Gaiteri +100 more
TL;DR: A colocalization analysis is applied to identify genes underlying the GWAS association peaks for schizophrenia and identify a potentially novel gene colocalized with lncRNA RP11-677M14.
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An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.
Annalisa Cavallini,Suzanne C. Brewerton,Amanda J. Bell,Samantha Sargent,Sarah Glover,Clare Hardy,Roger Moore,John N. Calley,Devaki Ramachandran,Michael Poidinger,Eric Karran,Peter Davies,Michael Hutton,Philip G. Szekeres,Suchira Bose +14 more
TL;DR: GSK3α, GSK3β, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes associated with AD.
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BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders
Christian Schubert,Patricio O'Donnell,Jie Quan,Jens R. Wendland,Hualin S. Xi,Ashley R. Winslow,Enrico Domenici,Laurent Essioux,Tony Kam-Thong,David C. Airey,John N. Calley,David A. Collier,Hong Wang,Brian J. Eastwood,Philip J. Ebert,Yushi Liu,Laura Nisenbaum,Cara L. Ruble,James E. Scherschel,Ryan M. Smith,Hui-Rong Qian,Kalpana M. Merchant,Michael Didriksen,Mitsuyuki Matsumoto,Takeshi Saito,Nicholas J. Brandon,Alan J. Cross,Qi Wang,Husseini K. Manji,Hartmuth C. Kolb,Maura L. Furey,Wayne C. Drevets,Joo Heon Shin,Andrew E. Jaffe,Yankai Jia,Richard E. Straub,Amy Deep-Soboslay,Thomas M. Hyde,Joel E. Kleinman,Daniel R. Weinberger +39 more
TL;DR: An ambitious project to characterize the genetic and epigenetic regulation of multiple facets of transcription in distinct brain regions across the human lifespan in samples of major neuropsychiatric disorders and controls is outlined.
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Assessment of Diet‐induced Obese Rats as an Obesity Model by Comparative Functional Genomics
Shuyu Li,Hong-Yan Zhang,Charlie C. Hu,Frank Lawrence,Kelly E. Gallagher,Anupama Surapaneni,Shawn T. Estrem,John N. Calley,Gabor Varga,Ernst R. Dow,Yanyun Chen +10 more
TL;DR: A comparative functional genomics approach was applied to evaluate whether diet‐induced obese (DIO) rats serve as an effective obesity model.
Journal ArticleDOI
Genomic characterization of intrinsic and acquired resistance to cetuximab in colorectal cancer patients
Steven M. Bray,Jeeyun Lee,Seung Tae Kim,Joon Young Hur,Philip J. Ebert,John N. Calley,Isabella H. Wulur,Thejaswini Gopalappa,Swee Seong Wong,Hui Rong Qian,Jason C. Ting,Jiangang Liu,Melinda D. Willard,Ruslan D. Novosiadly,Young Suk Park,Joon Oh Park,Ho Yeong Lim,Won Ki Kang,Amit Aggarwal,Hee Cheol Kim,Christoph Reinhard +20 more
TL;DR: Novel genomic alterations are uncovered that elucidate the mechanisms of sensitivity and resistance to anti-EGFR therapy in metastatic CRC patients and show that PI3K/mTOR inhibition could rescue cetuximab resistance.