E
Eric Karran
Researcher at Heidelberg University
Publications - 22
Citations - 1453
Eric Karran is an academic researcher from Heidelberg University. The author has contributed to research in topics: Presenilin & Gene. The author has an hindex of 13, co-authored 22 publications receiving 1401 citations. Previous affiliations of Eric Karran include GlaxoSmithKline & University of South Florida.
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Journal ArticleDOI
The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families
Robert Clark,Mike Hutton,Rebecca A. Fuldner,Sue Froelich,Eric Karran,Christopher Talbot,Richard Crook,Corinne Lendon,Guy Prihar,C He,Kevin M. Korenblat,Alonso Martínez,Alonso Martínez,Michelle Wragg,F. Busfield,Maria I. Behrens,Amanda J. Myers,Joanne Norton,John C. Morris,N Mehta,Chad G. Pearson,Sarah Lincoln,M Baker,Karen Duff,C Zehr,Jordi Pérez-Tur,Harry Houlden,Adriana Ruiz,Jorge Ossa,Francisco Lopera,M. Arcos,Lucia Madrigal,John Collinge,C Humphreys,T Ashworth,S Sarner,Nick C. Fox,R Harvey,A Kennedy,P Roques,Cline Rt,Phillips Ca,Venter Jc,Lotta Forsell,Karin Axelman,Lena Lilius,Janet A. Johnston,R Cowburn,Matti Viitanen,Bengt Winblad,Ken Kosik,Matti Haltia,Minna Pöyhönen,Dennis W. Dickson,David G. Mann,D Neary,Julie S. Snowden,Peter L. Lantos,Lars Lannfelt,Martin N. Rossor,George Roberts,Mark Raymond Adams,John Hardy,Alison Goate +63 more
TL;DR: This work has localized the PS-1 gene to a 75 kb region and present the structure of this gene, evidence for alternative splicing and describe six novel mutations in early onset FAD pedigrees all of which alter residues conserved in the STM26 (Presenilin 2: PS-2) gene.
Journal ArticleDOI
Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response
Carol W. Gray,Robin V. Ward,Eric Karran,Sandra Turconi,Alison Rowles,Daniela Viglienghi,Christopher Southan,Amanda J. L. Barton,Kenneth Fantom,Andrew B. West,John Savopoulos,Namir J. Hassan,Helen Elizabeth SmithKline Beecham Clinkenbeard,Charles R. Hanning,Bernard Y. Amegadzie,John B. Davis,Colin Dingwall,George P. Livi,Caretha L. Creasy +18 more
TL;DR: The biochemical and sequence similarities between humHtrA2 and its bacterial homologues, in conjunction with its nuclear location and upregulation in response to tunicamycin and heat shock suggest that it is involved in mammalian stress response pathways.
Journal ArticleDOI
Fractionation and characterization of oligomeric, protofibrillar and fibrillar forms of beta-amyloid peptide.
Robin V. Ward,Kevin H. Jennings,Robert Jepras,William Neville,Davina E. Owen,Julie Hawkins,Gary Christie,John B. Davis,Ashley George,Eric Karran,David R. Howlett +10 more
TL;DR: A novel density-gradient centrifugation method is described for the isolation and characterization of structurally distinct polymerized forms of Abeta peptide, suggesting that both fibrillar and protofibrillsar species have the potential to be active in this assay.
Journal ArticleDOI
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.
Annalisa Cavallini,Suzanne C. Brewerton,Amanda J. Bell,Samantha Sargent,Sarah Glover,Clare Hardy,Roger Moore,John N. Calley,Devaki Ramachandran,Michael Poidinger,Eric Karran,Peter Davies,Michael Hutton,Philip G. Szekeres,Suchira Bose +14 more
TL;DR: GSK3α, GSK3β, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes associated with AD.
Journal ArticleDOI
Alzheimer's disease‐associated presenilin 1 in neuronal cells: Evidence for localization to the endoplasmic reticulum‐Golgi intermediate compartment
Janetta G. Culvenor,Fran Maher,Genevieve Evin,Fiorella Malchiodi-Albedi,Roberto Cappai,John R. Underwood,John B. Davis,Eric Karran,G.W. Roberts,Konrad Beyreuther,Colin L. Masters +10 more
TL;DR: Results indicate that PS1 is a resident protein of the ERGIC and could be involved in trafficking of proteins, including APP, between the ER and Golgi compartments.