S
Sudeshna Roy
Researcher at University of Mississippi
Publications - 27
Citations - 557
Sudeshna Roy is an academic researcher from University of Mississippi. The author has contributed to research in topics: Mitochondrial permeability transition pore & Bicyclic molecule. The author has an hindex of 13, co-authored 27 publications receiving 389 citations. Previous affiliations of Sudeshna Roy include University of North Carolina at Chapel Hill & Indian National Association.
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Journal ArticleDOI
HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells
Ranganayaki Muralidharan,Meghna Mehta,Rebaz Ahmed,Sudeshna Roy,Liang Xu,Jeffrey Aubé,Allshine Chen,Yan D. Zhao,Terence S. Herman,Rajagopal Ramesh,Anupama Munshi +10 more
TL;DR: A proof-of concept study results demonstrate CMLD-2 represents a promising HuR-targeted therapeutic class that with further development could lead to advanced preclinical studied and ultimately for lung cancer treatment.
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Synthesis of the C(18)−C(34) Fragment of Amphidinolide C and the C(18)−C(29) Fragment of Amphidinolide F
TL;DR: A convergent synthesis of the C(18)-C(34) fragment of amphidinolide C and the C-18-C(29) fragment from the common intermediate tetrahydrofuranyl-β-ketophosphonate is reported.
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Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis.
Xiaoqing Wu,Gulhumay Gardashova,Lan Lan,Shuang Han,Cuncong Zhong,Rebecca T. Marquez,Lanjing Wei,Spencer Wood,Sudeshna Roy,Sudeshna Roy,Ragul Gowthaman,John Karanicolas,Fei P. Gao,Dan A. Dixon,Danny R. Welch,Ling Li,Min Ji,Jeffrey Aubé,Liang Xu +18 more
TL;DR: An inhibitor to the RNA-binding protein HuR, KH-3, is identified that disrupts the interaction between HuR and target RNAs and inhibits human cancer growth and metastasis in mouse xenograft assays.
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Development of (E)-2-((1,4-dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide, ML336: Novel 2-amidinophenylbenzamides as potent inhibitors of venezuelan equine encephalitis virus.
Chad E. Schroeder,Tuanli Yao,Julie Sotsky,Robert A. Smith,Sudeshna Roy,Yong Kyu Chu,Haixun Guo,Nichole A. Tower,James W. Noah,Sara McKellip,Melinda Sosa,Lynn Rasmussen,Layton H. Smith,E. Lucile White,Jeffrey Aubé,Colleen B. Jonsson,Donghoon Chung,Jennifer E. Golden +17 more
TL;DR: Scaffold optimization revealed a novel rearrangement affording amidines, specifically compound 45, which was found to potently inhibit several VEEV strains in the low nanomolar range without cytotoxicity while limiting in vitro viral replication.
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Discovery, Synthesis, and Optimization of Diarylisoxazole-3-carboxamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore.
Sudeshna Roy,Justina Šileikytė,Marco Schiavone,Benjamin Neuenswander,Francesco Argenton,Jeffrey Aubé,Michael P Hedrick,Thomas D.Y. Chung,Michael Forte,Paolo Bernardi,Frank J. Schoenen +10 more
TL;DR: The therapeutic potential and in vivo efficacy of one of the most potent analogues, N‐(3‐chloro‐2‐methylphenyl)‐5‐(4‐fluoro‐3‐hydroxyphenyl)isoxazole‐ 3‐carboxamide (60), was validated in a biologically relevant zebrafish model of collagen VI congenital muscular dystrophies.