Showing papers by "Suet Yi Leung published in 2018"
TL;DR: A primary gastric cancer organoid biobank that comprises normal, dysplastic, cancer, and lymph node metastases from 34 patients, including detailed whole-exome and transcriptome analysis, provides a useful resource for studying both cancer cell biology and precision cancer therapy.
393 citations
TL;DR: A critical repressive function for PRMT6 is described in maintenance of HCC cells by regulating RAS binding and MEK/ERK signaling via methylation of CRAF on arginine 100.
71 citations
TL;DR: A set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC is developed, and the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture.
Abstract: Aberrant promoter methylation is a common mechanism for tumor suppressor inactivation in cancer. We develop a set of tools to identify genome-wide DNA methylation in distal regions with causal effect on tumorigenesis called MICMIC. Many predictions are directly validated by dCas9-based epigenetic editing to support the accuracy and efficiency of our tool. Oncogenic and lineage-specific transcription factors are shown to aberrantly shape the methylation landscape by modifying tumor-subtype core regulatory circuitry. Notably, the gene regulatory networks orchestrated by enhancer methylation across different cancer types are seen to converge on a common architecture. MICMIC is available on https://github.com/ZhangJlab/MICMIC
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21 citations
01 Feb 2018
TL;DR: It is hypothesised that the combination of disease self-management intervention and cognitive training will improve diabetic control in cognitively impaired older diabetic patients.
Abstract: Older diabetic people are at risk of cognitive decline and dementia.1 Cognitively impaired older diabetic patients may be more frail and more prone to problems with drug adherence than their cognitively normal counterparts. This results in poorer diabetic control and long-term complications. Chronic disease self-management programmes (CDSMPs) have been shown to have long-lasting effects on self-efficacy and health care utilisation. A locally adapted 6-week, group-based CDSMP has shown significant improvement in older people with chronic diseases in terms of self-management behaviours, self-efficacy, and subjective healthrelated quality of life, particularly in mental health.2 Nonetheless, the benefits of CDSMP may be limited in cognitively impaired older diabetic patients. Cognitive training has been shown to be effective in improving cognitive function in older people. A locally designed cognitive training programme for older people with subjective memory complaint has shown benefits in reasoning and memory after 12 weeks’ training in those with primary or lower education.3 A combination of this cognitive training programme and CDSMP may promote self-management activities and improve glycaemic control in cognitively impaired older diabetic patients. It is hypothesised that the combination of disease self-management intervention and cognitive training will improve diabetic control in such patients. We also examined changes in disease self-management habits, psychological health, Hong Kong Med J 2018;24(Suppl 2):S16-20 HHSRF project number: 10110581
3 citations