S
Sug Hyung Lee
Researcher at Catholic University of Korea
Publications - 463
Citations - 23933
Sug Hyung Lee is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Frameshift mutation & Germline mutation. The author has an hindex of 64, co-authored 454 publications receiving 21552 citations. Previous affiliations of Sug Hyung Lee include Chung-Ang University & The Catholic University of America.
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Mutational and expressional analysis of ERBB3 gene in common solid cancers.
TL;DR: The data suggest that ER BB3 is altered in GC and CRC by various ways, including somatic mutations and increased expression that might play roles in tumorigenesis, and an increased intensity of phosphorylated ERBB3 (pERBB3) inGC and CRC.
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Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway
TL;DR: It is suggested that nutlin-3-activated ERK1/2 may stimulate the transcription of BCL2A1 via the activation of ELK1, and BCL 2A1 expression may contribute to the inhibitory effect of ERK 1/2 on nutlin -3- induced apoptosis, thereby constituting a negative feedback loop of p53-induced apoptosis.
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Somatic mutation and loss of expression of a candidate tumor suppressor gene TET3 in gastric and colorectal cancers.
TL;DR: The data may indicate TET3 harbored not only frameshift mutation but also loss of expression, which together could play a role in tumorigenesis of GC and CRC with MSI-H by inhibiting TSG functions of Tet3.
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Expression of 15-hydroxyprostaglandin dehydrogenase, a COX-2 antagonist and tumour suppressor, is not altered in gastric carcinomas
TL;DR: In this article, upregulation of cyclooxygenase-2 (COX•2) plays crucial roles in tumorigenesis of gastrointestinal cancers, and administration of COX-2 inhibitors is known to reduce the risk of cancer developm...
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Mutational analysis of CASP10 gene in acute leukaemias and multiple myelomas
TL;DR: The data indicate that somatic mutation of CASP10 is not common in T‐ALL and MM, and suggest a possibility that CASP 10 mutation might contribute to the pathogenesis of factions of T‐all and MM.