S
Sug Hyung Lee
Researcher at Catholic University of Korea
Publications - 463
Citations - 23933
Sug Hyung Lee is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Frameshift mutation & Germline mutation. The author has an hindex of 64, co-authored 454 publications receiving 21552 citations. Previous affiliations of Sug Hyung Lee include Chung-Ang University & The Catholic University of America.
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Prognostic significance of O6-methylguanine DNA methyltransferase and p57 methylation in patients with diffuse large B-cell lymphomas.
TL;DR: It is demonstrated that aberrant promoter methylation of MGMT and p57 is an additional biological marker for predicting increased overall survival in patients with DLBCL.
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Autotaxin (lysoPLD/NPP2) protects fibroblasts from apoptosis through its enzymatic product, lysophosphatidic acid, utilizing albumin-bound substrate.
Jaehwi Song,Timothy Clair,Ji Heon Noh,Jung Woo Eun,So Yeon Ryu,Shi Nae Lee,Young-Min Ahn,Su Young Kim,Sug Hyung Lee,Won Sang Park,Nam Jin Yoo,Jung Young Lee,Suk Woo Nam +12 more
TL;DR: It is demonstrated that ATX is a key regulator of extracellular lysophosphatidic acid (LPA) that can act as survival factor, in addition to its mitogenic activity in mouse fibroblasts, and interventions to correct dysfunction in conditions of tumor cell growth and metastasis are suggested.
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Absence of nucleophosmin 1 (NPM1) gene mutations in common solid cancers
TL;DR: The data indicate that N PM1 exon 12 is mutated in AMLs, but not in other common human cancers, and suggest that the NPM1 mutation may not play a role in the tumorigenesis of common solid cancers.
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ERBB2 kinase domain mutation in a gastric cancer metastasis.
Jong Woo Lee,Young Hwa Soung,Su Young Kim,Won Sang Park,Suk Woo Nam,Sang Ho Kim,Jung Young Lee,Nam Jin Yoo,Sug Hyung Lee +8 more
TL;DR: The data suggest that ERBB2 kinase domain mutation occasionally occurs in metastatic Gastric carcinoma and might play a role in the metastatic process of some gastric carcinomas.
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Immune checkpoint blockade resistance-related B2M hotspot mutations in microsatellite-unstable colorectal carcinoma.
Su Yeon Yeon,Seung-Hyun Jung,Yun Sol Jo,Eun Ji Choi,Min Sung Kim,Yeun-Jun Chung,Sug Hyung Lee +6 more
TL;DR: The results show that B2M mutation is common in MSU CRCs, which is one of the main targets for ICB treatment, suggesting that frequent B 2M mutation status should be reminded for MSu CRCs in patient selection of ICB.