S
Sug Hyung Lee
Researcher at Catholic University of Korea
Publications - 463
Citations - 23933
Sug Hyung Lee is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Frameshift mutation & Germline mutation. The author has an hindex of 64, co-authored 454 publications receiving 21552 citations. Previous affiliations of Sug Hyung Lee include Chung-Ang University & The Catholic University of America.
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Journal ArticleDOI
Mutational analysis of the CASP6 gene in colorectal and gastric carcinomas.
Jong Woo Lee,Mee Ran Kim,Young Hwa Soung,Suk Woo Nam,Sang Ho Kim,Jung Young Lee,Nam Jin Yoo,Sug Hyung Lee +7 more
TL;DR: The data indicate that the CASP6 gene is occasionally mutated in gastric and colorectal carcinomas, and the data suggest the possibility that deficiency of caspase‐6 expression might contribute to the pathogenesis of gastric cancers.
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The mutational burdens and evolutionary ages of early gastric cancers are comparable to those of advanced gastric cancers.
Tae-Min Kim,Seung-Hyun Jung,Min Sung Kim,In-Pyo Baek,Sung-Won Park,Sung Hak Lee,Han Hong Lee,Sung Soo Kim,Yeun-Jun Chung,Sug Hyung Lee +9 more
TL;DR: The results suggest that the genetic makeup for gastric cancer may already be achieved in EGC genomes and that the time required for transition to AGC may be relatively short, and suggest a possibility that the mutational profiles obtained from early biopsies may be useful in the clinical settings for the molecular diagnosis and therapeutics of gastric patients.
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Somatic mutations of BECN1, an autophagy-related gene, in human cancers.
TL;DR: The first report on BECN1 gene mutations in human cancer tissues is reported, and the data suggest that point mutations are a rare event in common human cancers and probably do not play a major role in cancer pathogenesis.
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Immunohistochemical analysis of NF‐κB signaling proteins IKKε, p50/p105, p52/p100 and RelA in prostate cancers
Seong Il Seo,Sang Yong Song,Mi Ran Kang,Min Sung Kim,Ji Eun Oh,Yoo Ri Kim,Ji Youl Lee,Nam Jin Yoo,Sug Hyung Lee +8 more
TL;DR: Immunohistochemical analysis of NF‐κB signaling proteins IKKε, p50/p105, p52/p100 and RelA in prostate cancers shows positive associations with disease progression in men and women.
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Laminin gene LAMB4 is somatically mutated and expressionally altered in gastric and colorectal cancers.
TL;DR: The data show that frameshift mutations of LAMA1, LAMA3, LAMB1 and LAMb4, and loss of L AMB4 may be features of GC and CRC with MSI‐H.