S
Sug Hyung Lee
Researcher at Catholic University of Korea
Publications - 463
Citations - 23933
Sug Hyung Lee is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Frameshift mutation & Germline mutation. The author has an hindex of 64, co-authored 454 publications receiving 21552 citations. Previous affiliations of Sug Hyung Lee include Chung-Ang University & The Catholic University of America.
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Expression of CARD6, an NF-κB activator, in gastric, colorectal and oesophageal cancers
TL;DR: The increased expression of CARD 6 in ESCC, GC and CRC tissues compared to their corresponding normal cells suggested that neoexpression of CARD6 might be related to activation of NF‐κB pathway in the cancers and might play a role in the development of most types of gastrointestinal cancers.
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Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability.
TL;DR: The data indicate that frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability and suggest that these alterations might contribute to cancer pathogenesis by deregulating cohesin-related functions.
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Immunohistochemical and mutational analysis of apoptosis-inducing factor (AIF) in colorectal carcinomas†
Eun Goo Jeong,Jong Woo Lee,Young Hwa Soung,Suk Woo Nam,Sang Ho Kim,Jung Young Lee,Nam Jin Yoo,Sug Hyung Lee +7 more
TL;DR: The increased expression of AIF in the malignant colorectal epithelial cells compared to the normal mucosal epithelium cells suggests that AIF expression may play a role in colOREctal tumorigenesis, and the data suggest that somatic mutation of Aif is a rare event in common human cancers.
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Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation
Nahyeon Kang,Nahyeon Kang,Su Yeon Choi,Su Yeon Choi,Bit Na Kim,Bit Na Kim,Chang Dong Yeo,Chang Dong Yeo,Chan Kwon Park,Chan Kwon Park,Young Kyoon Kim,Tae-Jung Kim,Seong-Beom Lee,Sug Hyung Lee,Jong Y. Park,Mi Sun Park,Hyeon Woo Yim,Seung Joon Kim,Seung Joon Kim +18 more
TL;DR: Hypoxia-induced acquisition of cancer stem cell characteristics was associated with CXCR4 activation by its aberrant promoter demethylation, which functionally resulted in the EMT and cancer stemness acquisition.
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Frequent frameshift mutations in 2 mononucleotide repeats of RNF43 gene and its regional heterogeneity in gastric and colorectal cancers
TL;DR: The data indicate that RNF43 gene harbored not only exceedingly high mutations but also mutational ITH, which together might play a role in tumorigenesis of GC and CRC and suggest that regional analysis is required for a more comprehensive evaluation of the mutation status in these tumors.