S
Sug Hyung Lee
Researcher at Catholic University of Korea
Publications - 463
Citations - 23933
Sug Hyung Lee is an academic researcher from Catholic University of Korea. The author has contributed to research in topics: Frameshift mutation & Germline mutation. The author has an hindex of 64, co-authored 454 publications receiving 21552 citations. Previous affiliations of Sug Hyung Lee include Chung-Ang University & The Catholic University of America.
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Journal ArticleDOI
Inactivating mutations of the Siah-1 gene in gastric cancer.
Chang Jae Kim,Yong Gu Cho,Cho Hyun Park,Seong-Whan Jeong,Suk Woo Nam,Su Young Kim,Sug Hyung Lee,Nam Jin Yoo,Jung Young Lee,Won Sang Park +9 more
TL;DR: The data suggest that inactivating mutations of the Siah-1 may contribute to the development of gastric cancer through β-catenin stabilization and apoptosis block.
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ERBB2 kinase domain mutation in the lung squamous cell carcinoma.
Jong Woo Lee,Young Hwa Soung,Su Young Kim,Suk Woo Nam,Won Sang Park,Young Pil Wang,Keon Hyun Jo,Seok Whan Moon,Sang Yong Song,Jung Young Lee,Nam Jin Yoo,Sug Hyung Lee +11 more
TL;DR: It is demonstrated that in addition to lung adenocarcinoma ERBB2 kinase domain mutation could occur in lung squamous cell carcinomas, and suggested that alterations of ER BB2-mediated signaling pathway by ERBB1 mutations may occasionally contribute to the development of lung squamy cell carcinoma.
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Mutational analysis of the ARAF gene in human cancers.
Jong Woo Lee,Young Hwa Soung,Su Young Kim,Won Park,Suk Woo Nam,Woo Sung Min,Sang Ho Kim,Jung Young Lee,Nam Jin Yoo,Sug Hyung Lee +9 more
TL;DR: The data indicate that, in contrast to the BRAF gene, the ARAF gene is rarely mutated in human cancers, and suggest that alterations of the RAS pathway by ARAf gene mutation may not play an important role in the pathogenesis of human cancers.
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Immunohistochemical localization of FAP‐1, an inhibitor of Fas‐mediated apoptosis, in normal and neoplastic human tissues
Sug Hyung Lee,Min Sun Shin,Won Sang Park,Su Young Kim,Hong Sug Kim,Jong Heun Lee,Seo Young Han,Hun Kyung Lee,Jik Young Park,Ro Ra Oh,Ja June Jang,Jung Young Lee,Nam Jin Yoo +12 more
TL;DR: It is demonstrated that F AP‐1 is widely expressed in normal human tissues and partly overlapped with Fas expression described in earlier reports, suggesting that FAP‐1 may have an important role in the regulation of apoptosis in vivo.
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Increased expression of Gab2, a scaffolding adaptor of the tyrosine kinase signalling, in gastric carcinomas.
TL;DR: Gab2 over‐expression is a feature not only of breast cancers, but also of gastric cancers, and increased expression of Gab2 in malignant gastric cells compared with normal epithelial cells suggests that Gab2 expression may play a role in gastric cancer development.