Suk Yun Kang

TL;DR: It is demonstrated that the sigma-1 receptor-induced increase in spinal pNR1 expression is mediated by the PKCalpha and PKC epsilon isoforms, which in turn contribute to the pain facilitation phenomenon.

TL;DR: Data demonstrate a sequential role for P2Y1R, p38 MAPK and TRPV1 in inflammation-induced thermal hyperalgesia; thus, peripheral P2y1Rs activation modulates p38MAPK signaling and TRpV1 expression, which ultimately leads to the induction of thermal hyperAlgesia.

TL;DR: Mechanistic information that repetitive treatment of DBV can produce more potent analgesic effect than single DBV treatment is provided, indicating a potential novel strategy for the management of chronic pain.

TL;DR: It is demonstrated that spinal IL‐1&bgr; suppresses Cx43 expression and astrocyte activation during the early phase of CA‐induced inflammation resulting in the delayed onset of contralateral MA.

TL;DR: It is demonstrated that the increase in spinal p-p38 MAPK is closely associated with the induction of Sig-1R mediated MA, but not TH, and Sigma-1 receptor modulation of p- p38MAPK also plays an important role in the induction, butNot the maintenance, of MA in neuropathic pain.