S
Sumio Sugano
Researcher at University of Tokyo
Publications - 394
Citations - 34789
Sumio Sugano is an academic researcher from University of Tokyo. The author has contributed to research in topics: Gene & Complementary DNA. The author has an hindex of 76, co-authored 393 publications receiving 31681 citations. Previous affiliations of Sumio Sugano include Tokyo Medical and Dental University & Rockefeller University.
Papers
More filters
Journal ArticleDOI
Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.
Meiri Shida,Akihiko Arakawa,Ryohei Ishii,S. Kishishita,Tetsuo Takagi,Mutsuko Kukimoto-Niino,Sumio Sugano,Akiko Tanaka,Mikako Shirouzu,Shigeyuki Yokoyama +9 more
TL;DR: The crystal structures of the human Hsp70 nucleotide-binding domain (NBD) fragment were determined in the nucleophile-free state and in complex with adenosine 5'-(beta,gamma-imido)triphosphate (AMPPNP).
Journal ArticleDOI
Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form
Noriko Handa,S. Kishishita,Satoshi Morita,Ryogo Akasaka,Zhongmin Jin,John Chrzas,Lirong Chen,Zhi-Jie Liu,Bi-Cheng Wang,Sumio Sugano,Akiko Tanaka,Takaho Terada,Mikako Shirouzu,Shigeyuki Yokoyama +13 more
TL;DR: A comparison with the yeast homolog revealed that lipid binding induces conformational changes around the alpha1-alpha2 loop, leading to slippage of thealpha1 helix along the large beta-sheet, which may play important roles in the translocation of polypeptides across the mitochondrial inner membrane.
Journal ArticleDOI
dbQSNP: A database of SNPs in human promoter regions with allele frequency information determined by single-strand conformation polymorphism-based methods
Tomoko Tahira,Shingo Baba,Koichiro Higasa,Yoji Kukita,Yutaka Suzuki,Sumio Sugano,Kenshi Hayashi +6 more
TL;DR: A fraction of the SNPs revealed a significantly different allele frequency between the groups, suggesting differential selection of the genes involved and the need for population‐based collections and allele frequency determination of SNPs, in, e.g., association studies of diseases.
Journal ArticleDOI
Aberrant autophosphorylation of c-Kit receptor in canine mast cell tumor cell lines.
Yoshinori Takeuchi,Yasuhito Fujino,Manabu Watanabe,Takayuki Nakagawa,Koichi Ohno,Nobuo Sasaki,Sumio Sugano,Hajime Tsujimoto +7 more
TL;DR: Investigation of mechanisms of c-Kit receptor activation in various canine MCT cell lines indicated that consistent c- Kit receptor phosphorylation could be caused by the stimulation with autocrine SCF in HRMC cells while it could be cause by functional mutations of KIT in VIMC1, CoMS1 and CMMC1 cells.
Journal ArticleDOI
Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization.
TL;DR: DNA immunization using GroEL might become a standard method for producing antibodies that are useful for the functional analysis of GPCRs, and could be used in immunoassays, such as flow cytometry, western blotting, and immunoprecipitation.