S
Suraya Roslan
Researcher at University of South Australia
Publications - 9
Citations - 2391
Suraya Roslan is an academic researcher from University of South Australia. The author has contributed to research in topics: Epithelial–mesenchymal transition & Cancer. The author has an hindex of 7, co-authored 7 publications receiving 1882 citations. Previous affiliations of Suraya Roslan include South Australia Pathology.
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Journal ArticleDOI
The RNA binding protein quaking regulates formation of circRNAs.
Simon J. Conn,Katherine A. Pillman,Katherine A. Pillman,John Toubia,John Toubia,Vanessa M. Conn,Marika Salmanidis,Caroline A Phillips,Caroline A Phillips,Suraya Roslan,Andreas W. Schreiber,Andreas W. Schreiber,Andreas W. Schreiber,Philip A. Gregory,Philip A. Gregory,Gregory J. Goodall,Gregory J. Goodall +16 more
TL;DR: It is shown that hundreds of circRNAs are regulated during human epithelial-mesenchymal transition (EMT) and that the production of over one-third of abundant circ RNAs is dynamically regulated by the alternative splicing factor, Quaking (QKI), which itself is regulated during EMT.
Journal ArticleDOI
An autocrine TGF-β/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
Philip A. Gregory,Cameron P. Bracken,Cameron P. Bracken,Eric Smith,Andrew G. Bert,Josephine A. Wright,Josephine A. Wright,Suraya Roslan,Melanie Morris,Leila Wyatt,Leila Wyatt,Gelareh Farshid,Yat-Yuen Lim,Yat-Yuen Lim,Yat-Yuen Lim,Geoffrey J. Lindeman,M. Frances Shannon,Paul A. Drew,Yeesim Khew-Goodall,Yeesim Khew-Goodall,Gregory J. Goodall,Gregory J. Goodall +21 more
TL;DR: A signaling network involving autocrine TGF-β signaling, ZEB transcription factors, and the miR-200 family regulates interconversion between epithelial and mesenchymal states.
Journal ArticleDOI
MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways
X Li,Suraya Roslan,Cameron N. Johnstone,Josephine A. Wright,Cameron P. Bracken,M Anderson,Andrew G. Bert,Luke A. Selth,Robin L. Anderson,Gregory J. Goodall,Philip A. Gregory,Yeesim Khew-Goodall +11 more
TL;DR: Findings highlight the context-dependent effects of miR-200 in breast cancer metastasis and demonstrate the existence of a moesin-dependent pathway, distinct from the ZEB1-E-cadherin axis, through which miR -200 can regulate tumour cell plasticity and metastasis.
Journal ArticleDOI
miR-200/375 control epithelial plasticity-associated alternative splicing by repressing the RNA-binding protein Quaking.
Katherine A. Pillman,Caroline A Phillips,Suraya Roslan,John Toubia,B. Kate Dredge,Andrew G. Bert,Rachael Lumb,Daniel P. Neumann,Xiaochun Li,Simon J. Conn,Simon J. Conn,Dawei Liu,Cameron P. Bracken,Cameron P. Bracken,David M. Lawrence,Nataly Stylianou,Andreas W. Schreiber,Wayne D. Tilley,Brett G. Hollier,Yeesim Khew-Goodall,Yeesim Khew-Goodall,Luke A. Selth,Gregory J. Goodall,Gregory J. Goodall,Philip A. Gregory,Philip A. Gregory +25 more
TL;DR: The existence of a miR‐200/miR‐375/QKI axis that impacts cancer‐associated epithelial cell plasticity through widespread control of alternative splicing is demonstrated.
Journal ArticleDOI
The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking
Leila Belle,Leila Belle,Naveid A. Ali,Ana Lonic,Ana Lonic,Xiaochun Li,James L. Paltridge,James L. Paltridge,Suraya Roslan,David Herrmann,James R.W. Conway,Freya Gehling,Andrew G. Bert,Lesley A. Crocker,Anna Tsykin,Gelareh Farshid,Gregory J. Goodall,Gregory J. Goodall,Paul Timpson,Roger J. Daly,Roger J. Daly,Yeesim Khew-Goodall,Yeesim Khew-Goodall +22 more
TL;DR: The tyrosine phosphatase PTPN14 (also called Pez, which is mutated in various cancers) suppressed metastasis by reducing intracellular protein trafficking through the secretory pathway.