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Brett G. Hollier
Researcher at Queensland University of Technology
Publications - 74
Citations - 4286
Brett G. Hollier is an academic researcher from Queensland University of Technology. The author has contributed to research in topics: Metastasis & Prostate cancer. The author has an hindex of 33, co-authored 66 publications receiving 3747 citations. Previous affiliations of Brett G. Hollier include University of Texas MD Anderson Cancer Center & University of British Columbia.
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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
Joseph H. Taube,Jason I. Herschkowitz,Kakajan Komurov,Alicia Y. Zhou,Supriya Gupta,Jing Yang,Kimberly A. Hartwell,Tamer T. Onder,Piyush Gupta,Piyush Gupta,Kurt W. Evans,Brett G. Hollier,Prahlad T. Ram,Eric S. Lander,Jeffrey M. Rosen,Robert A. Weinberg,Sendurai A. Mani +16 more
TL;DR: The EMT core signature associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negatively with pathological complete response, and the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients.
The epithelial-to-mesenchymal transition and cancer stem cells : a coalition against cancer therapies
TL;DR: The EMT process may facilitate the generation of cancer cells with the mesenchymal traits needed for dissemination as well as the self-renewal properties needed for initiation of secondary tumors.
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The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies.
TL;DR: In this article, the authors discuss the role of epithelial-to-mesenchymal transition (EMT) and stem cells in the progression of breast cancer and therapy resistance.
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Epithelial‐Mesenchymal Transition‐Derived Cells Exhibit Multilineage Differentiation Potential Similar to Mesenchymal Stem Cells
Venkata Lokesh Battula,Kurt W. Evans,Brett G. Hollier,Yuexi Shi,Frank C. Marini,Ayyakkannu Ayyanan,Rui Yu Wang,Cathrin Brisken,Rudy Guerra,Michael Andreeff,Sendurai A. Mani +10 more
TL;DR: It is demonstrated that the EMT‐derived cells are similar to MSCs in gene expression, multilineage differentiation, and ability to migrate towards tumor cells and wound sites.
Journal ArticleDOI
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer
Brett G. Hollier,Agata A. Tinnirello,Steven J. Werden,Kurt W. Evans,Joseph H. Taube,Tapasree Roy Sarkar,Nathalie Sphyris,Maryam Shariati,Sreedevi V. Kumar,Venkata Lokesh Battula,Jason I. Herschkowitz,Rudy Guerra,Jeffrey T. Chang,Naoyuki Miura,Jeffrey M. Rosen,Sendurai A. Mani +15 more
TL;DR: In this paper, it was shown that attenuation of FOXC2 expression using lentiviral short hairpin RNA led to inhibition of the mesenchymal phenotype and associated invasive and stem cell properties, which included reduced mammosphere forming ability and tumor initiation.