Martijn J. C. van Herwijnen

TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.

TL;DR: It is argued that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments and EV-TRACK, a crowdsourcing knowledgebase that centralizes EV biology and methodology, is described.

TL;DR: Mechanistic studies reveal that CD4+CD25+CD127lowFoxp3+ Tregs produce IL-10, IL-4, and IL-13 and that these cytokines are the critical factors involved in the suppression of the proinflammatory cytokine response.

TL;DR: A novel community-driven approach to build a comprehensive functional enrichment analysis tool using the existing FunRich tool as a template and inviting researchers to request additional features and/or changes was able to implement 90% of the requested features.

TL;DR: It was determined that storing unprocessed breast milk at −80°C or 4°C caused death of cells present in breast milk, leading to contamination of the breast milk EV population with storage-induced EV, and an alternative method is proposed to store breast milk samples for EV analysis at later time points.