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Susan Koujak
Researcher at Columbia University
Publications - 8
Citations - 1440
Susan Koujak is an academic researcher from Columbia University. The author has contributed to research in topics: PTEN & PI3K/AKT/mTOR pathway. The author has an hindex of 8, co-authored 8 publications receiving 1358 citations. Previous affiliations of Susan Koujak include Columbia University Medical Center.
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Journal ArticleDOI
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity
Lao H. Saal,Peter Johansson,Karolina Holm,Sofia K. Gruvberger-Saal,Qing-Bai She,Matthew J. Maurer,Susan Koujak,Adolfo A. Ferrando,Per-Uno Malmström,Lorenzo Memeo,Jorma Isola,Pär-Ola Bendahl,Neal Rosen,Hanina Hibshoosh,Markus Ringnér,Åke Borg,Ramon Parsons +16 more
TL;DR: It is indicated that aberrant PI3K pathway signaling is strongly associated with metastasis and poor survival across carcinoma types, highlighting the enormous potential impact on patient survival that pathway inhibition could achieve.
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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
Lao H. Saal,Sofia K. Gruvberger-Saal,Camilla Persson,Kristina Lövgren,Mervi Jumppanen,Johan Staaf,Göran Jönsson,Maira M. Pires,Matthew Maurer,Karolina Holm,Susan Koujak,Shivakumar Subramaniyam,Johan Vallon-Christersson,Håkan Olsson,Tao Su,Lorenzo Memeo,Thomas Ludwig,Stephen P. Ethier,Morten Krogh,Matthias Szabolcs,Vundavalli V. Murty,Jorma Isola,Hanina Hibshoosh,Ramon Parsons,Åke Borg +24 more
TL;DR: It is shown that heterozygous inactivation of the tumor suppressor gene Pten leads to the formation of basal-like mammary tumors in mice, and that loss of PTEN expression is significantly associated with the BBC subtype in human sporadic and BRCA1-associated hereditary breast cancers.
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Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a
Barry Fine,Cindy Hodakoski,Susan Koujak,Tao Su,Tao Su,Lao H. Saal,Matthew Maurer,Matthew Maurer,Benjamin D. Hopkins,Megan Keniry,Maria Luisa Sulis,Maria Luisa Sulis,Sarah M. Mense,Hanina Hibshoosh,Hanina Hibshoosh,Ramon Parsons,Ramon Parsons +16 more
TL;DR: P-REX2a is a component of the PI3K pathway that can antagonize PTEN in cancer cells and provides a mechanism through which tumor cells may inactivate PTEN, a tumor suppressor whose cellular regulation remains incompletely understood.
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PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer
Jennifer S. Yu,Susan Koujak,Satoru Nagase,Satoru Nagase,Chi Ming Li,Tao Su,Xiaomei Wang,Megan Keniry,Lorenzo Memeo,A. Rojtman,Mahesh Mansukhani,Hanina Hibshoosh,B. Tycko,Ramon Parsons +13 more
TL;DR: It is proposed that loss of PCDH8 promotes oncogenesis in epithelial human cancers by disrupting cell–cell communication dedicated to tissue organization and repression of mitogenic signaling.
Journal ArticleDOI
3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Matthew Maurer,Tao Su,Lao H. Saal,Susan Koujak,Benjamin D. Hopkins,Christina R. Barkley,Jiaping Wu,Subhadra V. Nandula,Bhaskar Dutta,Yuli Xie,Y. Rebecca Chin,Da In Kim,Jennifer S. Ferris,Sofia K. Gruvberger-Saal,Mervi Laakso,Xiaomei Wang,Lorenzo Memeo,Albert Rojtman,Tulio Matos,Jennifer S. Yu,Carlos Cordon-Cardo,Jorma Isola,Mary Beth Terry,Alex Toker,Gordon B. Mills,Jean J. Zhao,Vundavalli V. Murty,Hanina Hibshoosh,Ramon Parsons +28 more
TL;DR: It is argued that PDK1 overexpression and increased PDPK1 copy number are common occurrences in cancer that potentiate the oncogenic effect of upstream lesions on the PI3K pathway.