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Bhaskar Dutta
Researcher at National Institutes of Health
Publications - 31
Citations - 1875
Bhaskar Dutta is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Innate immune system & Signal transduction. The author has an hindex of 17, co-authored 31 publications receiving 1734 citations. Previous affiliations of Bhaskar Dutta include University of Maryland, College Park & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: This paper showed that SGK3 undergoes PI3K-and PDK1-dependent activation in PIK3CA mutant cancer cells and showed that these cells retain robust PDK 1 activation and membrane localization and exhibit dependency on the SGK 1 substrate SGK 3.
AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer
Krishna Murthi Vasudevan,David A. Barbie,David A. Barbie,Michael A. Davies,Rosalia Rabinovsky,Chontelle J. McNear,Jessica J. Kim,Bryan T. Hennessy,Hsiuyi Tseng,Panisa Pochanard,So Young Kim,So Young Kim,Ian F. Dunn,Anna C. Schinzel,Anna C. Schinzel,Peter Sandy,Sebastian Hoersch,Qing Sheng,Piyush Gupta,Jesse S. Boehm,Jan H. Reiling,Serena J. Silver,Yiling Lu,Katherine Stemke-Hale,Bhaskar Dutta,Corwin Joy,Aysegul A. Sahin,Ana M. Gonzalez-Angulo,Ana Lluch,Lucia E. Rameh,Tyler Jacks,David E. Root,Eric S. Lander,Gordon B. Mills,William C. Hahn,William R. Sellers,William R. Sellers,Levi A. Garraway +37 more
TL;DR: It is shown through phosphoprotein profiling and functional genomic studies that many PIK3CA mutant cancer cell lines and human breast tumors exhibit only minimal AKT activation and a diminished reliance on AKT for anchorage-independent growth.
Journal ArticleDOI
3-Phosphoinositide-Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Matthew Maurer,Tao Su,Lao H. Saal,Susan Koujak,Benjamin D. Hopkins,Christina R. Barkley,Jiaping Wu,Subhadra V. Nandula,Bhaskar Dutta,Yuli Xie,Y. Rebecca Chin,Da In Kim,Jennifer S. Ferris,Sofia K. Gruvberger-Saal,Mervi Laakso,Xiaomei Wang,Lorenzo Memeo,Albert Rojtman,Tulio Matos,Jennifer S. Yu,Carlos Cordon-Cardo,Jorma Isola,Mary Beth Terry,Alex Toker,Gordon B. Mills,Jean J. Zhao,Vundavalli V. Murty,Hanina Hibshoosh,Ramon Parsons +28 more
TL;DR: It is argued that PDK1 overexpression and increased PDPK1 copy number are common occurrences in cancer that potentiate the oncogenic effect of upstream lesions on the PI3K pathway.
Journal ArticleDOI
Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses
Rachel A. Gottschalk,Andrew J. Martins,Bastian R. Angermann,Bhaskar Dutta,Caleb E. Ng,Caleb E. Ng,Stefan Uderhardt,John S. Tsang,Iain D. C. Fraser,Martin Meier-Schellersheim,Ronald N. Germain +10 more
TL;DR: An evolutionarily conserved innate immune response system in which danger discrimination is enforced by distinct thresholds for NF-κB and MAPK activation, which provide sequential barriers to inflammatory mediator production is revealed.
Journal ArticleDOI
PathNet: a tool for pathway analysis using topological information
TL;DR: An algorithm (PathNet) is developed that utilizes the connectivity information in canonical pathway descriptions to help identify study-relevant pathways and characterize non-obvious dependencies and connections among pathways using gene expression data.