S
Sven W. Görgens
Researcher at University of Düsseldorf
Publications - 16
Citations - 1060
Sven W. Görgens is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Skeletal muscle & Myokine. The author has an hindex of 12, co-authored 15 publications receiving 833 citations.
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Journal ArticleDOI
Myokines in insulin resistance and type 2 diabetes.
TL;DR: The most recent findings on the role of myokines in the regulation of substrate metabolism and insulin sensitivity are summarized and a critical assessment of irisin and other myokine regarding their potential as therapeutic targets are provided.
Journal ArticleDOI
Contractile activity of human skeletal muscle cells prevents insulin resistance by inhibiting pro-inflammatory signalling pathways
S. Lambernd,Annika Taube,A. Schober,B. Platzbecker,Sven W. Görgens,Raphaela Schlich,K. Jeruschke,Jürgen Weiss,Kristin Eckardt,Jürgen Eckel +9 more
TL;DR: In this novel model, muscle contractile activity eliminates insulin resistance by blocking pro-inflammatory signalling pathways in human skeletal muscle cells, and provides a unique tool for investigating the molecular mechanisms that mediate the beneficial effects of muscle contraction.
Journal ArticleDOI
The myokine decorin is regulated by contraction and involved in muscle hypertrophy.
Timo Kanzleiter,Michaela Rath,Sven W. Görgens,Jørgen Jensen,Daniel S. Tangen,Anders J. Kolnes,Kristoffer Jensen Kolnes,Kristoffer Jensen Kolnes,Sindre Lee,Jürgen Eckel,Annette Schürmann,Kristin Eckardt +11 more
TL;DR: The findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle.
Journal ArticleDOI
Soluble DPP4 induces inflammation and proliferation of human smooth muscle cells via protease-activated receptor 2
Nina Wronkowitz,Sven W. Görgens,Tania Romacho,Laura A. Villalobos,Carlos F. Sánchez-Ferrer,Concepción Peiró,Henrike Sell,Jürgen Eckel +7 more
TL;DR: It is shown for the first time that sDPP4 directly activates the MAPK and NF-κB signaling cascade involving PAR2 and resulting in the induction of inflammation and proliferation of hVSMC.
Book ChapterDOI
Exercise and Regulation of Adipokine and Myokine Production
TL;DR: By using the adipo-myokine concept and including both skeletal muscle and adipose tissue, an attempt is made to gain a global view on the beneficial effects of different exercise programs and the underlying pathways.