S
Sylvie Darche
Researcher at Pasteur Institute
Publications - 28
Citations - 2503
Sylvie Darche is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 20, co-authored 28 publications receiving 2378 citations. Previous affiliations of Sylvie Darche include Institut Universitaire de France & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells
Kosuke Yusa,S. Tamir Rashid,Helene Strick-Marchand,Helene Strick-Marchand,Ignacio Varela,Pei-Qi Liu,David Paschon,Elena Miranda,Elena Miranda,Adriana Ordóñez,Nicholas R.F. Hannan,Foad J. Rouhani,Foad J. Rouhani,Sylvie Darche,Sylvie Darche,Graeme J.M. Alexander,Stefan J. Marciniak,Noemi Fusaki,Mamoru Hasegawa,Michael C. Holmes,James P. Di Santo,James P. Di Santo,David A. Lomas,Allan Bradley,Ludovic Vallier +24 more
TL;DR: This work shows that a combination of zinc finger nucleases (ZFNs) and piggyBac technology in human iPSCs can achieve biallelic correction of a point mutation in the α1-antitrypsin (A1AT, also known as SERPINA1) gene that is responsible for α1
Journal ArticleDOI
CD11c- and CD11b-expressing mouse leukocytes transport single Toxoplasma gondii tachyzoites to the brain
Nathalie Courret,Sylvie Darche,Pierre Sonigo,Geneviève Milon,Dominique Buzoni-Gâtel,Isabelle Tardieux +5 more
TL;DR: It is established that T. gondii zoites hijacked CD11b+ leukocytes to reach the brain extravascular space and triggered a parasitic process in the brain of naive recipient mice.
Journal Article
Differential cytokine expression in maternal blood and placenta during murine gestation.
TL;DR: The results show that pregnancy induces profound changes in the expression of these genes in peripheral blood cells, and IL-4, being the main cytokine, may play a major regulatory role in the context of the placenta as a privileged immune site.
Journal ArticleDOI
Extrathymic T cell lymphopoiesis: ontogeny and contribution to gut intraepithelial lymphocytes in athymic and euthymic mice.
Delphine Guy-Grand,Orly Azogui,Susanna Celli,Sylvie Darche,Michel C. Nussenzweig,Philippe Kourilsky,Pierre Vassalli +6 more
TL;DR: Assessing the expression of recombinase activating gene (RAG) through the use of green fluorescent protein RAG2 transgenic mouse models found that in normal animals, all gut T IEL, including CD8αα+ cells, are of thymic origin, CD8 αα+ TCRαβ+ IEL being the likely progeny of double negative NK1-1− thymocytes, which show polyclonal Vα and Vβ repertoires.
Journal ArticleDOI
TLR9 Is Required for the Gut-Associated Lymphoid Tissue Response following Oral Infection of Toxoplasma gondii
Laurie A. Minns,Laurence Menard,David M. Foureau,Sylvie Darche,Catherine Ronet,Daniel Mielcarz,Dominique Buzoni-Gatel,Lloyd H. Kasper +7 more
TL;DR: It is shown that TLR9 is required for the Th1-type inflammatory response that ensues following oral infection with T. gondii and is involved in the development of an effective Th 1-type immune response.