S
Sylwia Mazurek
Researcher at Poznan University of Medical Sciences
Publications - 10
Citations - 1343
Sylwia Mazurek is an academic researcher from Poznan University of Medical Sciences. The author has contributed to research in topics: Induced pluripotent stem cell & Cancer stem cell. The author has an hindex of 7, co-authored 10 publications receiving 634 citations. Previous affiliations of Sylwia Mazurek include Medical University of Warsaw.
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Journal ArticleDOI
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Tathiane M. Malta,Artem Sokolov,Andrew J. Gentles,Tomasz Burzykowski,Laila M. Poisson,John N. Weinstein,Bozena Kaminska,Joerg Huelsken,Larsson Omberg,Olivier Gevaert,Antonio Colaprico,Patrycja Czerwińska,Sylwia Mazurek,Lopa Mishra,Holger Heyn,Alexander Krasnitz,Andrew K. Godwin,Alexander J. Lazar,Joshua M. Stuart,Katherine A Hoadley,Peter W. Laird,Houtan Noushmehr,Maciej Wiznerowicz +22 more
TL;DR: Novel stemness indices for assessing the degree of oncogenic dedifferentiation are provided and it is found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors.
Journal ArticleDOI
The complexity of TRIM28 contribution to cancer.
TL;DR: Different aspects of TRIM28 involvement in regulation of cancer cell homeostasis which collectively imply pro-tumorigenic character of TRim28 are presented.
Journal ArticleDOI
TRIM28 multi-domain protein regulates cancer stem cell population in breast tumor development
Patrycja Czerwińska,Patrycja Czerwińska,Parantu K. Shah,Katarzyna Tomczak,Katarzyna Tomczak,Marta Klimczak,Sylwia Mazurek,Barbara Sozańska,Przemyslaw Biecek,Przemyslaw Biecek,Konstanty Korski,Violetta Filas,Andrzej Mackiewicz,Jannik N. Andersen,Maciej Wiznerowicz +14 more
TL;DR: The data demonstrate that the downregulation of TRIM28 gene expression reduced the ability of CSCs to self-renew that resulted in significant reduction of tumor growth, paving the way to novel and more effective therapies targeting cancer stem cells in breast tumors.
Journal ArticleDOI
TRIM28 epigenetic corepressor is indispensable for stable induced pluripotent stem cell formation.
Marta Klimczak,Patrycja Czerwińska,Sylwia Mazurek,Barbara Sozańska,Przemyslaw Biecek,Andrzej Mackiewicz,Maciej Wiznerowicz +6 more
TL;DR: It is demonstrated that Trim28 knockdown (Trim28 KD) causes that emerging iPS cells differentiate immediately back into MEFs therefore they fail to yield stable iPS cell colonies, suggesting regulation of epigenetic modifications coordinated by TRIM28 plays a crucial role in reprogramming process.
Journal ArticleDOI
Application of induced pluripotency in cancer studies.
TL;DR: Recent advances inReprogramming methodologies as well as commonalities between cell reprogramming and carcinogenesis are presented and recent outcomes from the implementation of induced pluripotency into cancer research are discussed.