T
T. Cameron Waller
Researcher at University of California, San Diego
Publications - 12
Citations - 346
T. Cameron Waller is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Metabolic network & Tumor microenvironment. The author has an hindex of 4, co-authored 10 publications receiving 201 citations. Previous affiliations of T. Cameron Waller include University of California, Berkeley & University of Utah.
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Journal ArticleDOI
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.
John C. Schell,Dona R. Wisidagama,Claire L. Bensard,Helong Zhao,Peng Wei,Jason M. Tanner,Aimee Flores,Jeffrey Mohlman,Lise K. Sorensen,Christian S. Earl,Kristofor A. Olson,Ren Miao,T. Cameron Waller,Don A. Delker,Priyanka Kanth,Lei Jiang,Lei Jiang,Ralph J. DeBerardinis,Mary P. Bronner,Dean Y. Li,James E. Cox,Heather R. Christofk,William E. Lowry,Carl S. Thummel,Jared Rutter +24 more
TL;DR: It is demonstrated that limiting mitochondrial pyruvate metabolism is necessary and sufficient to maintain the proliferation of intestinal stem cells and to understand the role this transition from glycolysis to pyruVate oxidation plays in stem cell maintenance and differentiation.
Journal ArticleDOI
IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival.
Alyssa Batista,Jeffrey J. Rodvold,Su Xian,Stephen C. Searles,Alyssa Lew,Takao Iwawaki,Gonzalo Almanza,T. Cameron Waller,Jonathan H. Lin,Kristen Jepsen,Hannah Carter,Maurizio Zanetti +11 more
TL;DR: It is reported that the inositol-requiring enzyme 1 (IRE1α) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1).
Journal ArticleDOI
Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.
Jason R. Nielson,Eric K. Fredrickson,T. Cameron Waller,Olga Zurita Rendón,Heidi L. Schubert,Zhenjian Lin,Christopher P. Hill,Jared Rutter +7 more
TL;DR: A 2.7 Å crystal structure of Vms1 is reported that reveals that the LRS lies in a hydrophobic groove in the autoinhibited MTD, which supports a model in which stressed mitochondria generate an oxidized sterol receptor that recruits VMS1 to support mitochondrial protein homeostasis.
Posted ContentDOI
The unfolded protein response links tumor aneuploidy to local immune dysregulation
Su Xian,Stephen C. Searles,Paras Sahani,T. Cameron Waller,Kristen Jepsen,Hannah Carter,Maurizio Zanetti +6 more
TL;DR: The UPR is proposed as a mechanistic link between aneuploidy and immune dysregulation in the tumor microenvironment and showed increased activity by multiple branches of the UPR in response to aneuPLoidy.
Journal ArticleDOI
The unfolded protein response links tumor aneuploidy to local immune dysregulation.
Su Xian,Magalie Dosset,Gonzalo Almanza,Stephen C. Searles,Paras Sahani,T. Cameron Waller,Kristen Jepsen,Hannah Carter,Maurizio Zanetti +8 more
TL;DR: In this paper, the unfolded protein response (UPR) was found to link aneuploidy and local immune dysregulation in a pan-cancer analysis of 9,375 samples in The Cancer Genome Atlas (TCGA) database.