L
Lei Jiang
Researcher at City of Hope National Medical Center
Publications - 49
Citations - 4159
Lei Jiang is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: Mitochondrion & Medicine. The author has an hindex of 20, co-authored 29 publications receiving 2983 citations. Previous affiliations of Lei Jiang include Chinese Academy of Sciences & Beckman Research Institute.
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Journal ArticleDOI
Metabolic Heterogeneity in Human Lung Tumors
Christopher T. Hensley,Brandon Faubert,Qing Yuan,Naama Lev-Cohain,Eunsook S. Jin,Jiyeon Kim,Lei Jiang,Bookyung Ko,Rachael Skelton,Laurin Loudat,Michelle Wodzak,Claire Klimko,Elizabeth A. McMillan,Yasmeen M. Butt,Min Ni,Dwight H Oliver,Jose R. Torrealba,Craig R. Malloy,Kemp H. Kernstine,Robert E. Lenkinski,Ralph J. DeBerardinis +20 more
TL;DR: These findings not only demonstrate the heterogeneity in tumor metabolism in vivo but also highlight the strong influence of the microenvironment on this feature.
Journal ArticleDOI
Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport
Chendong Yang,Bookyung Ko,Christopher T. Hensley,Lei Jiang,Ajla T. Wasti,Jiyeon Kim,Jessica Sudderth,MariaAntonietta Calvaruso,Lloyd Lumata,Matthew A. Mitsche,Jared Rutter,Matthew E. Merritt,Ralph J. DeBerardinis +12 more
TL;DR: This work shows that import of pyruvate into the mitochondria suppresses GDH and glutamine-dependent acetyl-CoA formation and defines a mechanism to induce glutaminolysis and uncover a survival pathway engaged during compromised supply of pyRuvate to the mitochondaria.
Journal ArticleDOI
Reductive carboxylation supports redox homeostasis during anchorage-independent growth
Lei Jiang,Alexander A. Shestov,Pamela Swain,Chendong Yang,Seth J. Parker,Qiong A. Wang,Lance S. Terada,Nicholas D. Adams,Michael T. McCabe,Beth Pietrak,Stan Schmidt,Christian M. Metallo,Brian P. Dranka,Benjamin Schwartz,Ralph J. DeBerardinis +14 more
TL;DR: The data indicate that adaptation to anchorage independence requires a fundamental change in citrate metabolism, initiated by IDH1-dependent reductive carboxylation and culminating in suppression of mitochondrial ROS.
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A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.
John C. Schell,Kristofor A. Olson,Lei Jiang,Amy J. Hawkins,Jonathan G. Van Vranken,Jianxin Xie,Robert A. Egnatchik,Espen G. Earl,Ralph J. DeBerardinis,Jared Rutter +9 more
TL;DR: It is proposed that reduced MPC activity is an important aspect of cancer metabolism, perhaps through altering the maintenance and fate of stem cells.
Journal ArticleDOI
Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.
Andrew R. Mullen,Zeping Hu,Xiaolei Shi,Lei Jiang,Lindsey K. Boroughs,Zoltan Kovacs,Richard L. Boriack,Dinesh Rakheja,Lucas B. Sullivan,W. Marston Linehan,Navdeep S. Chandel,Ralph J. DeBerardinis +11 more
TL;DR: The data demonstrate that reductive carboxylation requires bidirectional AKG metabolism along oxidative and reductive pathways, with the oxidative pathway producing reducing equivalents used to operate IDH in reverse.