T
Tadashi Tanabe
Researcher at University of Tokushima
Publications - 98
Citations - 8164
Tadashi Tanabe is an academic researcher from University of Tokushima. The author has contributed to research in topics: Peptide sequence & Gene. The author has an hindex of 45, co-authored 98 publications receiving 8002 citations. Previous affiliations of Tadashi Tanabe include Nagasaki University & University of Konstanz.
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Journal ArticleDOI
Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells
Kotha Subbaramaiah,Wen Jing Chung,Pedro Michaluart,Nitin T. Telang,Tadashi Tanabe,Hiroyasu Inoue,Mei-Shiang Jang,John M. Pezzuto,Andrew J. Dannenberg +8 more
TL;DR: It is found that resveratrol also directly inhibited the activity of COX-2, a phenolic antioxidant found in grapes and other food products, which is likely to be important for understanding the anti-cancer and anti-inflammatory properties of resver atrol.
Journal ArticleDOI
Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element
TL;DR: In this paper, the human PES-2 gene was found to be inducible by lipopolysaccharide (LPS) and 12-O-tetradecanoylphorbol-13-acetate (TPA) using transient transfection analysis.
Journal ArticleDOI
Cyclooxygenase isozymes and their gene structures and expression
Tadashi Tanabe,Norimitsu Tohnai +1 more
TL;DR: The cyclooxygenase (COX, prostaglandin endoperoxide synthase) is a key enzyme in prostaglandsin biosynthesis and MAPK signaling pathways are involved in regulating COX-2 gene expression at the post-transcriptional level.
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Characterization of the human gene (PTGS2) encoding prostaglandin‐endoperoxide synthase 2
Tetsuya Kosaka,Atsuro Miyata,Hayato Ihara,Shuntaro Hara,Tamiko Sugimoto,Osamu Takeda,Ei-ichi Takahashi,Tadashi Tanabe +7 more
TL;DR: A fluorescence in situ hybridization study showed that the human genes coding for prostaglandin-endoperoxide synthase 1 (PTGS1) and prostaglandsin- endoperoxide-synthase 2 (PT GS2) were mapped to distinct chromosomes 9q32-q33.3 and 1q25.3, respectively, indicating that these genes are not genetically linked.
Journal Article
Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.
Pedro Michaluart,Jaime L. Masferrer,Adelaide M. Carothers,Kotha Subbaramaiah,Ben S. Zweifel,Carol M. Koboldt,Juan R. Mestre,Dezider Grunberger,Peter G. Sacks,Tadashi Tanabe,Andrew J. Dannenberg +10 more
TL;DR: In the rat carrageenan air pouch model of inflammation, CAPE caused dose-dependent suppression of PG synthesis and the effects of TPA and CAPE were localized to a 124-bp region of the COX-2 promoter.