T
Taiichi Katayama
Researcher at University of Toronto
Publications - 4
Citations - 1462
Taiichi Katayama is an academic researcher from University of Toronto. The author has contributed to research in topics: Presenilin & APH-1. The author has an hindex of 3, co-authored 4 publications receiving 1389 citations. Previous affiliations of Taiichi Katayama include Toronto Western Hospital & Hamamatsu University School of Medicine.
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Journal ArticleDOI
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Ekaterina Rogaeva,Ekaterina Rogaeva,Yan Meng,Joseph H. Lee,Yongjun Gu,Yongjun Gu,Toshitaka Kawarai,Toshitaka Kawarai,Fanggeng Zou,Taiichi Katayama,Taiichi Katayama,Clinton T. Baldwin,Rong Cheng,Hiroshi Hasegawa,Hiroshi Hasegawa,Fusheng Chen,Fusheng Chen,Nobuto Shibata,Nobuto Shibata,Kathryn L. Lunetta,Raphaëlle Pardossi-Piquard,Raphaëlle Pardossi-Piquard,Christopher Bohm,Christopher Bohm,Yosuke Wakutani,Yosuke Wakutani,L. Adrienne Cupples,Karen T. Cuenco,Robert C. Green,Lorenzo Pinessi,Innocenzo Rainero,Sandro Sorbi,Amalia C. Bruni,Ranjan Duara,Ranjan Duara,Robert P. Friedland,Rivka Inzelberg,Wolfgang Hampe,Hideaki Bujo,You-Qiang Song,Olav M. Andersen,Thomas E. Willnow,Neill R. Graff-Radford,Ronald C. Petersen,Dennis W. Dickson,Sandy D. Der,Sandy D. Der,Paul E. Fraser,Paul E. Fraser,Gerold Schmitt-Ulms,Gerold Schmitt-Ulms,Steven G. Younkin,Richard Mayeux,Lindsay A. Farrer,Lindsay A. Farrer,Peter St George-Hyslop,Peter St George-Hyslop +56 more
TL;DR: It is reported here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease, and it is shown that SOR l1 directs trafficking of APP into recycling pathways and that when SORl1 is underexpressed, APP is sorted into Aβ-generating compartments.
Journal ArticleDOI
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Fusheng Chen,Hiroshi Hasegawa,Hiroshi Hasegawa,Gerold Schmitt-Ulms,Toshitaka Kawarai,Christopher Bohm,Taiichi Katayama,Yongjun Gu,Nobuo Sanjo,Nobuo Sanjo,Michael Glista,Ekaterina Rogaeva,Yosuke Wakutani,Raphaëlle Pardossi-Piquard,Xueying Ruan,Anurag Tandon,Frédéric Checler,Philippe Marambaud,Kirk C. Hansen,David Westaway,Peter St George-Hyslop,Peter St George-Hyslop,Paul E. Fraser +22 more
TL;DR: It is reported that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates γ- secretase cleavage without affecting ɛ-secretase activity.
Journal ArticleDOI
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
Hiroshi Hasegawa,Nobuo Sanjo,Fusheng Chen,Yongjun Gu,Cortney Shier,Agnes Petit,Toshitaka Kawarai,Taiichi Katayama,Stephen D. Schmidt,Paul M. Mathews,Gerold Schmitt-Ulms,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop +13 more
TL;DR: Deletion and mutagenesis studies suggest that both the presence and amino acid sequence of the conserved DYLSF domain at the C terminus of PEN-2 (residues 90–94) is critical for binding P EN-2 to other components in the presenilin complex and the overall length of the exposed C termini is criticalFor functional γ-secretase activity.
Journal ArticleDOI
Localization and trafficking of endogenous anterior pharynx-defective 1, a component of Alzheimer's disease related γ-secretase
Nobuo Sanjo,Taiichi Katayama,Taiichi Katayama,Hiroshi Hasegawa,Hiroshi Hasegawa,Haifeng Jin,Monika Duthie,Howard T.J. Mount,Hidehiro Mizusawa,Peter St George-Hyslop,Paul E. Fraser +10 more
TL;DR: Fractionation and immunofluorescence studies indicated that the endogenous full-length Aph-1aL isoform localizes primarily to the endoplasmic reticulum as well as Golgi intermediate compartment, but small amount of it was detected at Golgi apparatus where most of its carboxyl terminal domain fragment existed.