T
Taina Härkönen
Researcher at University of Helsinki
Publications - 13
Citations - 592
Taina Härkönen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Disease. The author has an hindex of 10, co-authored 13 publications receiving 447 citations. Previous affiliations of Taina Härkönen include Helsinki University Central Hospital.
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Journal ArticleDOI
Intestinal virome changes precede autoimmunity in type I diabetes-susceptible children.
Guoyan Zhao,Tommi Vatanen,Tommi Vatanen,Lindsay Droit,Arnold Park,Aleksandar Kostic,Tiffany W. Poon,Hera Vlamakis,Heli Siljander,Heli Siljander,Taina Härkönen,Taina Härkönen,Anu Maaria Hämäläinen,Aleksandr Peet,Aleksandr Peet,Vallo Tillmann,Vallo Tillmann,Jorma Ilonen,David Wang,Mikael Knip,Ramnik J. Xavier,Ramnik J. Xavier,Herbert W. Virgin +22 more
TL;DR: It was found that the intestinal viromes of cases were less diverse than those of controls and eukaryotic viruses and bacteriophage contigs that are associated with the presence or absence of autoimmunity and disease-associated viral bacteriophile contigs were statistically linked to specific components of the bacterial microbiome.
Journal ArticleDOI
Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study
Outi Vaarala,Jorma Ilonen,Terhi Ruohtula,Jouni Pesola,Suvi M. Virtanen,Taina Härkönen,Matti Koski,Harri Kallioinen,Olli Tossavainen,Tuija Poussa,Anna-Liisa Järvenpää,Jorma Komulainen,R Lounamaa,H. K. Åkerblom,Mikael Knip +14 more
TL;DR: In comparison with ordinary CMF, weaning to an insulin-free CMF reduced the cumulative incidence of autoantibodies by age 3 years in children at genetic risk of type 1 diabetes mellitus.
Removal of Bovine Insulin From Cow's Milk Formula and Early Initiation of Beta-Cell Autoimmunity in the FINDIA Pilot Study
Outi Vaarala,Jorma Ilonen,Terhi Ruohtula,Jouni Pesola,Suvi M. Virtanen,Taina Härkönen,Matti Koski,Harri Kallioinen,Olli Tossavainen,Tuija Poussa,Anna-Liisa Järvenpää,Jorma Komulainen,R Lounamaa,H. K. Åkerblom,Mikael Knip +14 more
TL;DR: In this article, a double-blind pilot trial was conducted to test whether weaning to a bovine insulin-free cow's milk formula (CMF) reduces type 1 diabetes mellitusassociated autoantibodies in children at genetic risk.
Journal ArticleDOI
Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity.
Jorma Ilonen,Johanna Lempainen,Anna Hammais,Antti-Pekka Laine,Taina Härkönen,Jorma Toppari,Riitta Veijola,Mikael Knip +7 more
TL;DR: The relationship between patterns of isletAutoantibodies at diagnosis and specificity of the first islet autoantibody at the initiation of autoimmunity was analyzed with the aim of identifying patterns informative of the primary autoantsibodies.
Journal ArticleDOI
Early life origin of type 1 diabetes
TL;DR: Putative endogenous factors that may contribute to the development of T1D during fetal and early postnatal life are discussed, some of them most likely already during pregnancy.