K
Kristiina Luopajärvi
Researcher at University of Helsinki
Publications - 14
Citations - 1219
Kristiina Luopajärvi is an academic researcher from University of Helsinki. The author has contributed to research in topics: Type 1 diabetes & Downregulation and upregulation. The author has an hindex of 9, co-authored 13 publications receiving 1008 citations. Previous affiliations of Kristiina Luopajärvi include Helsinki University Central Hospital & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Fecal Microbiota Composition Differs Between Children With β-Cell Autoimmunity and Those Without
Marcus C. de Goffau,Kristiina Luopajärvi,Mikael Knip,Jorma Ilonen,Jorma Ilonen,Terhi Ruohtula,Taina Härkönen,L. Orivuori,Saara Hakala,Gjalt W. Welling,Hermie J. M. Harmsen,Outi Vaarala +11 more
TL;DR: Functional studies related to the observed alterations in the gut microbiome are warranted because the low abundance of bifidobacteria and butyrate-producing species could adversely affect the intestinal epithelial barrier function and inflammation, whereas the apparent importance of the Bacteroides genus in development of type 1 diabetes is insufficiently understood.
Journal ArticleDOI
IL-17 Immunity in Human Type 1 Diabetes
Jarno Honkanen,Janne K. Nieminen,Ru Gao,Kristiina Luopajärvi,Harri M. Salo,Jorma Ilonen,Jorma Ilonen,Mikael Knip,Timo Otonkoski,Outi Vaarala +9 more
TL;DR: It is demonstrated that IL-17 had detrimental effects on human islet cells in vitro; it potentiated both inflammatory and proapoptotic responses.
Journal ArticleDOI
Genomic variation and strain-specific functional adaptation in the human gut microbiome during early life.
Tommi Vatanen,Damian R. Plichta,Juhi Somani,Philipp C. Münch,Timothy D. Arthur,Andrew Brantley Hall,Sabine Rudolf,Edward J. Oakeley,Xiaobo Ke,Xiaobo Ke,Rachel A. Young,Henry J. Haiser,Raivo Kolde,Moran Yassour,Moran Yassour,Kristiina Luopajärvi,Heli Siljander,Suvi M. Virtanen,Suvi M. Virtanen,Jorma Ilonen,Jorma Ilonen,Raivo Uibo,Vallo Tillmann,Sergei Mokurov,Natalya Dorshakova,Jeffrey A. Porter,Alice C. McHardy,Harri Lähdesmäki,Hera Vlamakis,Curtis Huttenhower,Curtis Huttenhower,Mikael Knip,Ramnik J. Xavier +32 more
TL;DR: Integration of longitudinal gut metagenomic datasets from children in Finland, Estonia and Russian Karelia reveals high strain-level diversity, which consequently impacts the functional capabilities of the early life microbiome.
Journal ArticleDOI
Enhanced levels of cow’s milk antibodies in infancy in children who develop type 1 diabetes later in childhood
Kristiina Luopajärvi,Erkki Savilahti,Suvi M. Virtanen,Jorma Ilonen,Jorma Ilonen,Mikael Knip,Hans K. Åkerblom,Outi Vaarala +7 more
TL;DR: This data indicates that early exposure to cow’s milk proteins have been implicated in the pathogenesis of type 1 diabetes (T1D) and this work aims to establish a causal link between these proteins and T1D.
Journal ArticleDOI
Th1/Th17 Plasticity Is a Marker of Advanced β Cell Autoimmunity and Impaired Glucose Tolerance in Humans
Linnea Reinert-Hartwall,Jarno Honkanen,Harri M. Salo,Janne Nieminen,Kristiina Luopajärvi,Kristiina Luopajärvi,Taina Härkönen,Riitta Veijola,Olli Simell,Jorma Ilonen,Jorma Ilonen,Aleksandr Peet,Vallo Tillmann,Mikael Knip,Outi Vaarala,Outi Vaarala,Katriina Koski,Matti Koski,Samppa J. Ryhänen,Anu-Maaria Hämäläinen,Anne Ormisson,Valentina Ulich,Elena Kuzmicheva,Sergei Mokurov,Svetlana Markova,Svetlana Pylova,Marina Isakova,Elena Shakurova,Vladimir Petrov,Natalya Dorshakova,Tatyana Karapetyan,Tatyana Varlamova,Minna Kiviniemi,Kristi Alnek,Helis Janson,Raivo Uibo,Tiit Salum,Erika von Mutius,Juliane Weber,Helena Ahlfors,Henna Kallionpää,Essi Laajala,Riitta Lahesmaa,Harri Lähdesmäki,Robert Moulder,Janne K. Nieminen,Terhi Ruohtula,Hanna Honkanen,Heikki Hyöty,Anita Kondrashova,Sami Oikarinen,Hermie J. M. Harmsen,Marcus C. de Goffau,Gjalt W. Welling,Kirsi Alahuhta,Suvi M. Virtanen +55 more
TL;DR: It is demonstrated that the upregulation of the IL-17 pathway and Th1/Th17 plasticity in peripheral blood are markers of advanced β cell autoimmunity and impaired β cell function in human type 1 diabetes.