T
Takashi Tsukamoto
Researcher at Johns Hopkins University
Publications - 91
Citations - 4465
Takashi Tsukamoto is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Glutamate carboxypeptidase II & Glutaminase. The author has an hindex of 29, co-authored 78 publications receiving 3802 citations. Previous affiliations of Takashi Tsukamoto include Johns Hopkins University School of Medicine & Chiba University.
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Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide 3 (BPTES) analogs as glutaminase inhibitors.
Krupa Shukla,Dana Ferraris,Ajit G. Thomas,Marigo Stathis,Bridget Duvall,Greg Delahanty,Jesse Alt,Rana Rais,Camilo Rojas,Ping Gao,Yan Xiang,Chi V. Dang,Barbara S. Slusher,Takashi Tsukamoto +13 more
TL;DR: In an attempt to identify more potent GLS inhibitors with improved drug-like molecular properties, a series of BPTES analogs were synthesized and evaluated and revealed that some truncated analogs retained the potency of B PTES, presenting an opportunity to improve its aqueous solubility.
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Synthesis and biological evaluation of D-amino acid oxidase inhibitors.
Dana Ferraris,Bridget Duvall,Yao Sen Ko,Ajit G. Thomas,Camilo Rojas,Pavel Majer,Kenji Hashimoto,Takashi Tsukamoto +7 more
TL;DR: Oral administration of CBIO in conjunction with d-serine enhanced the plasma and brain levels of d-Serine in rats compared to the oral administration of d -serine alone.
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Inhibition of glutaminase selectively suppresses the growth of primary acute myeloid leukemia cells with IDH mutations
TL;DR: This study lays the groundwork for strategies to target a specific subtype of AML metabolically with IDH mutations with a unique reprogramming of intermediary metabolism that culminates in glutamine dependency of cancer cells for survival.
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High-affinity near-infrared fluorescent small-molecule contrast agents for in vivo imaging of prostate-specific membrane antigen.
Valerie Humblet,Rena G. Lapidus,Larry R. Williams,Takashi Tsukamoto,Camilo Rojas,Pavel Majer,Bunda Hin,Shunsuke Ohnishi,Alec M. De Grand,Atif Zaheer,Jürgen T. Renze,Akira Nakayama,Barbara S. Slusher,John V. Frangioni +13 more
TL;DR: Nearly complete preclinical development of an optically based small-molecule contrast agent for image-guided surgery is described and sensitive and specific in vitro imaging of endogenous and ectopically expressed PSMA in human cells and in vivo imaging of xenograft tumors is demonstrated.
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Synthesis and biological evaluation of thiol-based inhibitors of glutamate carboxypeptidase II: discovery of an orally active GCP II inhibitor.
Pavel Majer,Paul F. Jackson,Greg Delahanty,Brian Grella,Yao Sen Ko,Weixing Li,Qun Liu,Maclin Keith M,Jana Polakova,Kathryn Ann Shaffer,Doris Stoermer,Dilrukshi Vitharana,Eric Wang,Anthony Zakrzewski,Camilo Rojas,Barbara S. Slusher,Krystyna M. Wozniak,Eric Burak,Tharin Limsakun,Takashi Tsukamoto +19 more
TL;DR: The most potent thiol-based inhibitor, 2-(3-mercaptopropyl)pentanedioic acid (IC(50) = 90 nM), was found to be orally bioavailable in rats and exhibited efficacy in an animal model of neuropathic pain following oral administration.