T
Takayuki Matsuoka
Researcher at University of Tokyo
Publications - 5
Citations - 249
Takayuki Matsuoka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Receptor & TLR4. The author has an hindex of 4, co-authored 5 publications receiving 227 citations.
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Journal ArticleDOI
The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide.
Kumi Izawa,Yoshinori Yamanishi,Akie Maehara,Mariko Takahashi,Masamichi Isobe,Shinichi Ito,Ayako Kaitani,Toshihiro Matsukawa,Takayuki Matsuoka,Fumio Nakahara,Toshihiko Oki,Hiroshi Kiyonari,Takaya Abe,Ko Okumura,Toshio Kitamura,Jiro Kitaura +15 more
TL;DR: It is shown that leukocyte mono-immunoglobulin-like receptor 3 (LMIR3; also called CD300f) is a negative regulator of MC activation in vivo, and the interaction between extracellular ceramide and LMIR3 suppressed MC-dependent allergic responses.
Journal ArticleDOI
An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcRγ in Mast Cells
Kumi Izawa,Jiro Kitaura,Yoshinori Yamanishi,Takayuki Matsuoka,Ayako Kaitani,Masahiro Sugiuchi,Mariko Takahashi,Akie Maehara,Yutaka Enomoto,Toshihiko Oki,Toshiyuki Takai,Toshio Kitamura +11 more
TL;DR: LMIR3 crosslinking enhanced cytokine production of BMMCs stimulated by LPS, while suppressing production stimulated by other TLR agonists or stem cell factor, and thereby functions as an activating receptor in concert with TLR4 stimulation.
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Functional Analysis of Activating Receptor LMIR4 as a Counterpart of Inhibitory Receptor LMIR3
Kumi Izawa,Jiro Kitaura,Yoshinori Yamanishi,Takayuki Matsuoka,Toshihiko Oki,Fumi Shibata,Hidetoshi Kumagai,Hideaki Nakajima,Mari Maeda-Yamamoto,Jeffrey P. Hauchins,Victor L. J. Tybulewicz,Toshiyuki Takai,Toshio Kitamura +12 more
TL;DR: Results suggest that the innate immune system is at least in part regulated by the qualitative and quantitative balance of the paired receptors LMIR3 and LMIR4.
Journal ArticleDOI
Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells
Yoshinori Yamanishi,Jiro Kitaura,Kumi Izawa,Takayuki Matsuoka,Toshihiko Oki,Yang Lu,Fumi Shibata,Satoshi Yamazaki,Hidetoshi Kumagai,Hideaki Nakajima,Mari Maeda-Yamamoto,Victor L. J. Tybulewicz,Toshiyuki Takai,Toshio Kitamura +13 more
TL;DR: Although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions ofLMIR5 were differentially regulated in mouse versus human cells.