Journal ArticleDOI
Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells
Yoshinori Yamanishi,Jiro Kitaura,Kumi Izawa,Takayuki Matsuoka,Toshihiko Oki,Yang Lu,Fumi Shibata,Satoshi Yamazaki,Hidetoshi Kumagai,Hideaki Nakajima,Mari Maeda-Yamamoto,Victor L. J. Tybulewicz,Toshiyuki Takai,Toshio Kitamura +13 more
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TLDR
Although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions ofLMIR5 were differentially regulated in mouse versus human cells.About:
This article is published in Blood.The article was published on 2008-01-15. It has received 50 citations till now. The article focuses on the topics: Degranulation & Cytokine.read more
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DAP10- and DAP12-associated receptors in innate immunity
TL;DR: DAP10‐ and DAP12‐associated receptors have been shown to recognize both host‐encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.
Journal ArticleDOI
The CD300 molecules: an emerging family of regulators of the immune system.
TL;DR: A review is provided on the cellular distribution of the human and mouse families of receptors, the stimuli that regulate their expression, their ability to tune leukocyte function and immune responses, their signaling pathways, ligand recognition, and their clinical relevance.
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The CD300 family of molecules are evolutionarily significant regulators of leukocyte functions.
TL;DR: Their ability to fine tune leukocyte function and immune responses highlights several potential options to exploit the CD300 molecules as therapeutic targets in chronic inflammatory diseases, allergy and other disease states.
Journal ArticleDOI
Positive and Negative Signals in Mast Cell Activation
TL;DR: The biological and clinical relevance of negative and positive signaling modalities that control mast cell activation are discussed, with an emphasis on novel FcεRI regulators, immunoglobulin E (IgE)-independent pathways, and the CD300 family of inhibitory and activating receptors.
Journal ArticleDOI
TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
Yoshinori Yamanishi,Jiro Kitaura,Kumi Izawa,Ayako Kaitani,Yukiko Komeno,Masaki Nakamura,Satoshi Yamazaki,Yutaka Enomoto,Toshihiko Oki,Hisaya Akiba,Takaya Abe,Tadasuke Komori,Yoshihiro Morikawa,Hiroshi Kiyonari,Toshiyuki Takai,Ko Okumura,Toshio Kitamura +16 more
TL;DR: The results indicate that TIM1 is an endogenous ligand for LMIR5 and that the TIM1–LMIR5 interaction plays a physiological role in immune regulation by myeloid cells.
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IgG Fc Receptors
TL;DR: Fc gamma Rs offer a paradigm for the biological significance of balancing activation and inhibitory signaling in the expanding family of activation/inhibitory receptor pairs found in the immune system.
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Plat-E: an efficient and stable system for transient packaging of retroviruses.
TL;DR: Plat-E as mentioned in this paper is a cell line based on the 293T cell line, which uses EF1 alpha promoter and the Kozak consensus sequence upstream of the initiation codon to ensure high and stable expression of viral structural proteins.
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Immune inhibitory receptors.
TL;DR: A central paradigm has emerged in which the pairing of activation and inhibition is necessary to initiate, amplify, and then terminate immune responses in mice with targeted disruption of inhibitory receptors.
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Mast cells in the development of adaptive immune responses
TL;DR: Mast cells may influence the development, intensity and duration of adaptive immune responses that contribute to host defense, allergy and autoimmunity, rather than simply functioning as effector cells in these settings.
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Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes.
TL;DR: TREM-1 mediates activation of neutrophil and monocytes, and may have a predominant role in inflammatory responses.