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Yuzo Koda
Researcher at Keio University
Publications - 13
Citations - 445
Yuzo Koda is an academic researcher from Keio University. The author has contributed to research in topics: Medicine & Immune system. The author has an hindex of 5, co-authored 8 publications receiving 209 citations. Previous affiliations of Yuzo Koda include Mitsubishi Tanabe Pharma.
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Journal ArticleDOI
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis
Nobuhiro Nakamoto,Nobuo Sasaki,Nobuo Sasaki,Ryo Aoki,Ryo Aoki,Kentaro Miyamoto,Wataru Suda,Wataru Suda,Toshiaki Teratani,Takahiro Suzuki,Yuzo Koda,Yuzo Koda,Po Sung Chu,Nobuhito Taniki,Akihiro Yamaguchi,Mitsuhiro Kanamori,Nobuhiko Kamada,Masahira Hattori,Masahira Hattori,Hiroshi Ashida,Michiie Sakamoto,Koji Atarashi,Seiko Narushima,Akihiko Yoshimura,Kenya Honda,Toshiro Sato,Takanori Kanai,Takanori Kanai +27 more
TL;DR: Klebsiella pneumoniae from the gut microbiota of patients with primary sclerosing cholangitis can damage the intestinal epithelial barrier, resulting in bacterial translocation and T helper 17 cell responses in the liver, indicating a role in PSC pathogenesis.
Journal ArticleDOI
Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice.
Nobuhiro Nakamoto,Takeru Amiya,Takeru Amiya,Ryo Aoki,Ryo Aoki,Nobuhito Taniki,Yuzo Koda,Yuzo Koda,Kentaro Miyamoto,Toshiaki Teratani,Takahiro Suzuki,Sayako Chiba,Po Sung Chu,Atsushi Hayashi,Akihiro Yamaguchi,Shunsuke Shiba,Rei Miyake,Tadashi Katayama,Wataru Suda,Wataru Suda,Yohei Mikami,Nobuhiko Kamada,Hirotoshi Ebinuma,Hidetsugu Saito,Masahira Hattori,Masahira Hattori,Takanori Kanai +26 more
TL;DR: It is found that recruitment of immune-regulatory classical dendritic cells (cDCs) is crucial for liver tolerance in concanavalin A-induced acute liver injury and that beneficial gut microbes influence tolerogenic immune responses in the liver.
Journal ArticleDOI
CD8+ tissue-resident memory T cells promote liver fibrosis resolution by inducing apoptosis of hepatic stellate cells
Yuzo Koda,Yuzo Koda,Toshiaki Teratani,Po Sung Chu,Yuya Hagihara,Yohei Mikami,Yosuke Harada,Hanako Tsujikawa,Kentaro Miyamoto,Takahiro Suzuki,Nobuhito Taniki,Tomohisa Sujino,Michiie Sakamoto,Takanori Kanai,Takanori Kanai,Nobuhiro Nakamoto +15 more
TL;DR: In this article, using a murine diet-induced NASH and the subsequent resolution model, the authors demonstrate direct roles of CD8+ tissue-resident memory CD8+, T (CD8+ Trm) cells in resolving liver fibrosis.
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Toll-Like Receptor 7 Agonist-Induced Dermatitis Causes Severe Dextran Sulfate Sodium Colitis by Altering the Gut Microbiome and Immune Cells.
Hiroki Kiyohara,Tomohisa Sujino,Toshiaki Teratani,Kentaro Miyamoto,Mari Mochizuki Arai,Ena Nomura,Yosuke Harada,Ryo Aoki,Yuzo Koda,Yohei Mikami,Shinta Mizuno,Makoto Naganuma,Tadakazu Hisamatsu,Takanori Kanai,Takanori Kanai +14 more
TL;DR: The finding of a novel potential skin–gut interaction provides new insights into the coincidence of psoriasis and IBD, and suggests that skin inflammation may contribute to pathogenic conditions in the gut via immunologic and microbiological changes.
Journal ArticleDOI
Role of CC chemokine receptor 9 in the progression of murine and human non-alcoholic steatohepatitis
Rei Morikawa,Nobuhiro Nakamoto,Takeru Amiya,Takeru Amiya,Po Sung Chu,Yuzo Koda,Yuzo Koda,Toshiaki Teratani,Takahiro Suzuki,Yutaka Kurebayashi,Akihisa Ueno,Nobuhito Taniki,Kentaro Miyamoto,Akihiro Yamaguchi,Shunsuke Shiba,Tadashi Katayama,Kosuke Yoshida,Yoshiaki Takada,Rino Ishihara,Hirotoshi Ebinuma,Hirotoshi Ebinuma,Michiie Sakamoto,Takanori Kanai +22 more
TL;DR: It is shown that CCR9 blockade attenuated the development of NAFLD-related hepatocellular carcinoma in mice injected with diethylnitrosamine under HF diet, providing new insights into therapeutic strategies for NASH.