T
Takeru Higuchi
Researcher at University of Wisconsin-Madison
Publications - 206
Citations - 11538
Takeru Higuchi is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Aqueous solution & Solubility. The author has an hindex of 37, co-authored 206 publications receiving 11032 citations. Previous affiliations of Takeru Higuchi include Smith, Kline & French & Merck & Co..
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Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices
TL;DR: The analyses suggest that for the latter system the time required to release 50% of the drug would normally be expected to be approximately 10 per cent of that required to dissolve the last trace of the solid drug phase in the center of the pellet.
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Rate of release of medicaments from ointment bases containing drugs in suspension
TL;DR: An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.
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Dissolution Behavior of Crystalline Solvated and Nonsolvated Forms of Some Pharmaceuticals
Eli Shefter,Takeru Higuchi +1 more
TL;DR: The results suggest that the tendency of many drugs to form such adducts provide pharmaceutical investigators a powerful tool in effecting rapid dissolution of highly insoluble substances.
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Naphthalene-2,3-dicarboxyaldehyde/cyanide ion: a rationally designed fluorogenic reagent for primary amines
Pierre. De Montigny,John F. Stobaugh,Richard S. Givens,Robert G. Carlson,Kasturi Srinivasachar,Larry A. Sternson,Takeru Higuchi +6 more
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Polymorphism and drug availability. Solubility relationships in the methylprednisolone system
TL;DR: The thermodynamic relationships involving polymorphism and solubility were examined in some detail and applied to experimental results with the methylprednisolone system and indicate that much more energetic crystal forms are probable.